Role of anti-Ro autoantibodies in systemic lupus erythematosus patients with recurrent myositis
Notice bibliographique
Résumé
Anti-SSA (Ro) autoantibodies have been detected in primary Sjögren's syndrome as well as in patients with other systemic autoimmune diseases including systemic lupus erythematosus (SLE). Recent studies have suggested a possible association of anti-Ro antibodies in patients with systemic sclerosis and myositis [ 1 ]. These autoantibodies have also been detected in patients with the anti-synthetase antibody syndrome [ 2 ]. We investigated the association of anti-Ro antibodies in SLE patients with myositis. In this retrospective study, we reviewed the records of 160 patients with SLE followed in the lupus clinic at LSU Health Sciences Center, Shreveport from 2000 to August 2012. We identified 16 patients (10%) with myositis and SLE. Patients with possible secondary cause of myositis, such as thyroid disease and drug, were excluded. All of the patients were females. Fourteen patients (87.5%) were African Americans and two (12.5%) were Caucasians with ages that ranged from 15 to 69 years. Among these 16 patients, 12 (75%) were found to have anti-Ro autoantibodies. The remaining four patients were not tested for anti-Ro. Five patients (41.7%) with higher levels of anti-Ro antibodies at the beginning of their disease experienced recurrences of the myositis. Average anti-Ro was compared between patients with and without recurrences to determine association between myositis recurrence and anti-Ro. A nonparametric test (Wilcoxon rank sum test) was used to do the comparison due the observed non-normal distribution of anti-Ro and the small sample sizes (five and seven) for the two groups compared. Mean ± SD for the recurrence and nonrecurrence groups was 470.4 ± 347.3 and 153.5 ± 113.4, respectively. Using the Wilcoxon rank sum test, the P value for the comparison was 0.06. This was not significant at the 5% level but significant at the 7% level ( P < 0.07). The observed nonsignificance at the 5% level was due to the small sizes (five and seven) for the two groups compared The observed results show possible association between myositis recurrence and anti-Ro antibody level. Prospective studies are required to further investigate this association. Myositis in SLE may be under-reported secondary to a lack of awareness of this association, which precludes the simultaneous testing of these autoantibodies along with muscle enzymes. This evaluation is vital during the beginning of disease and with flares because the ongoing muscle damage may be masked and undertreated by the subsequent therapy.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».