Effect of Cooling on the Glucoregulation of Anaesthetized and Non-Anaesthetized Newborn Dogs
Notice bibliographique
Résumé
UNLABELLED: When newborn dogs 2-14 days of age, anaesthetized with Nembutal, were cooled to 30 degrees C body core temperature, their rate of CO2 production (QCO2) decreased as predicted by van't Hoff's law, but the rates of hepatic glucose production and overall glucose utilization were decreased to a lesser degree, indicating an increase in the percentage contribution of plasma glucose to the overall energy turnover. In different litters of pups cooled to 32 degrees C, QCO2 and the rate of glucose production and utilization were decreased as predicted by van't Hoff's law. The metabolic clearance rate of glucose was decreased by cooling in all pups. These changes were wholly or partially reversible upon rewarming. Because of the approximate parallelity in the changes in the rates of production and utilization of glucose, no consistent change in blood glucose was observed during cooling. When non-anaesthetized pups less than 6 days old were exposed to cold until their core temperature was decreased to 32 degrees C QCO2 increased transiently during cooling. A small and transient elevation in plasma glucose concentration was observed due to a small increase in hepatic glucose production. Older pups fell into two categories: those which were able to maintain their body temperature by increasing their metabolic rate did not react with any change in their rates of glucose production and utilization. On the other hand pups which, during cooling, failed to raise their metabolic rate became hyperglycaemic because of an increased rate of glucose production and a decrease in glucose clearance. IN CONCLUSION: in anaesthetized pups QCO2 and the rates of hepatic glucose production and utilization follow approximately van't Hoff's law, indicating the absence of significant regulatory responses. Non-anaesthetized pups, if they are able to maintain their body temperature during cooling by an increase of their metabolic rate, show no significant changes in glucose production and utilization. Hyperglycaemia developed only in those pups which failed to increase their metabolic rate and consequently became severely hypothermic. In no case did hypothermia lead to hypoglycaemia.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».