Brain Injury after Transient Global Cerebral Ischemia and Subarachnoid Hemorrhage
Notice bibliographique
Résumé
Brain injury of diverse etiology is frequently encountered clinically. Management, thus, is diverse. Transient global ischemic (TGI) brain injury may result from cardiac arrest where cerebral perfusion diminishes to the point that blood supply can no longer meet the metabolic demand of the brain or from aneurysmal subarachnoid hemorrhage where hemorrhage from an intracranial aneurysm elevates the intracranial pressure above the blood pressure leading to momentary perfusion arrest. Though there are commonalities and differences in the etiology and pathogenesis of these two brain injuries, whether they required differential management or they can be grouped together is not clear. Some risk factors of TGI and SAH are shared and common and others are unique to the injury. Shared risk factors include high blood pressure, smoking, alcohol abuse, and stress. The risk factors unique to TGI are clinical conditions such as cardiac arrest (major cause), shock that creates prolonged hypoxia or hypoglycemia, pathologically elevated cerebral metabolic rate, or decreased cerebral perfusion pressure. The risk factor unique to SAH is the presence of an intracranial aneurysm. Other contrasting risk factors are age and gender; whereas old age increases the risk of TGI, SAH occurs in a younger population with an average age of 52–55 years. Women harbor significantly more intracranial aneurysms than men and consequently are more frequently the victims of SAH. Although the average age of women with SAH is greater than men, the outcome is similar [1]. In contrast, more men than women are at risk of ischemic stroke and women with ischemic stroke are usually older and more likely to die of stroke than men [2]. Brain injury after TGI can be separated into an initial ischemic phase that lasts for the duration that the brain blood supply remains reduced (usually ≤10 minutes, otherwise death is inevitable) and the reperfusion phase that begins immediately after reconstitution of cerebral blood supply (>10 minutes). The initial phase of brain injury after SAH is more complex and lasts for 48 to 72 hours. A complex series of events occurs during this initial (early) phase, including blood-induced mechanical trauma, oxyhemoglobin (released upon degradation of blood) induced oxidative stress, inflammation, and ischemia [3]. A delayed phase of brain injury, unique to SAH, develops 3–7 days after SAH. This injury is characterized by angiographic vasospasm and delayed cerebral ischemia [4]. In order to help understand the management of brain injury after TGI and SAH, this special issue compares and contrasts the various mechanisms of brain injury after TGI and SAH. It presents two original research articles and 7 reviews. The research article by C. S. Jung et al. studies the correlation of serum and CSF injury markers with ischemic events in SAH patients and that by S. O. Eicker et al. compares neuroprotective qualities of vascular endothelial drive growth factor (VEGF) against stroke and cerebral vasospasm after SAH. F. A. Sehba and R. M. Pluta review the existing TGI and aSAH animal models and present a modified aSAH model which effectively mimics the disease and has the potential of becoming a better resource for studying the brain injury mechanisms and developing a treatment. M. A. Kamp et al. review the mechanisms and clinical significance of the alteration in calcium and potassium channel after SAH and TGI. M. K. Tso and R. L. Macdonald review preclinical studies on microvascular changes and their therapeutic modification following SAH and TGI. N. Plesnila compares and contrasts pathophysiological events occurring in experimental models of SAH and TGI and evaluates the contribution and importance of global cerebral ischemia in the pathophysiology of SAH. M. Koide et al. summarize the current knowledge regarding the impact of SAH and global ischemia on neurovascular communication. J. A. Frontera reviews clinical trials in cardiac arrest and SAH and concludes that clinical trials in SAH assessing acute brain injury are conducted and that these trials may receive benefit from interventions identified successfully against brain injury following cardiac arrest. We hope that the present special issue stimulates further research in this topic and brings to attention the information that would provide a better understanding of the management of TGI and SAH patients. Fatima A. Sehba Ryszard M. Pluta R. Loch Macdonald
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».