Effects of feeding diets naturally contaminated with Fusarium mycotoxins on protein metabolism in late gestation and lactation of first-parity sows12
Notice bibliographique
Résumé
A study was conducted to assess the effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins to sows on the capacity for protein synthesis in skeletal muscle, the protein content per cellular unit, and the efficacy of a polymeric glucomannan adsorbent (GMA) to prevent these effects in late gestation and in lactation. Thirty-two Yorkshire sows were assigned to 4 treatment groups (8 per treatment) from 91 +/- 3 d of gestation up to weaning on d 21 after farrowing. Diets included 1) control, 2) contaminated grains, and 3) contaminated grains + 0.2% GMA. A fourth treatment of feeding sows the control diet at a restricted feed allowance was also included. The variables measured include ADFI, average daily BW change, serum total protein, urea, and ammonia, and skeletal muscle DNA, RNA, and protein. To assess the capacity for protein synthesis, ratios of RNA:DNA, and RNA:protein were compared among dietary treatments. To assess the degree of muscle protein mobilization in gestation and lactation, ratios of protein:DNA were compared among dietary treatments. Muscle samples were obtained from the triceps brachii. Blood and muscle samples were obtained 3 times: the first was obtained 1 d before the sows began to receive the experimental diets (90 +/- 3 d of gestation), a second sample was obtained 14 d later (104 +/- 3 d of gestation), and the third sample was obtained 10 d after farrowing. Serum ammonia concentrations were similar in sows fed the contaminated feed and sows fed the restricted feed compared with controls, but serum ammonia concentrations were greater in sows fed contaminated feed (P = 0.02) and restricted-fed sows (P = 0.008) compared with sows fed the contaminated grains plus GMA on 104 +/- 3 d of gestation. There were no reductions in the capacity for protein synthesis caused by mycotoxins or restricted feeding compared with controls. A reduction in ADFI (P = 0.003) was observed in sows fed the 2 contaminated diets in lactation. Muscle protein mobilization was not affected by diet, but a reduction (P = 0.04) in the content of protein per cellular unit was observed in lactation compared with gestation. Reduction in protein:DNA could be caused by the catabolic state in lactation, which was augmented by a low ADFI. The rate of muscle mobilization could be the result of the indirect effect of the reduction in ADFI in lactation rather than a direct effect of Fusarium mycotoxins in the capacity for protein synthesis.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».