Notice bibliographique
Résumé
Chronic wounds, especially on the feet, are a clinical feature resulting from diabetes and often result in limb amputation. Identification of strategies that promote closure of chronic wounds are essential. In a study authored by Henshaw et al. (J Diabetes Res. 2015;2015:236238), CCN2/CTGF was able to accelerated closure of wounds in diabetic rats. Moreover, in humans, the ability of wounds in diabetic patients to heal correlated with CCN2 expression. Thus CCN2 might, in the future, be used to promote healing of chronic wounds. Diabetic foot ulcers are a significant cause of morbidity and are a substantial financial burden. Approximately 25 % of diabetics have foot ulcers, and these account for up to 70 % of non traumatic lower limb amputations (Most and Sinnock 1983). About 6.5 million people in the USA suffer from chronic wounds, costing ~ $25 billion dollars (Sen et al. 2009). Developing novel methods of promoting closure of chronic diabetic wounds is therefore of paramount importance. CCN2 is a member of the CCN family of matricellular proteins that is induced by TGFβ and in response to wounding (Klaassen et al. 2015; Cicha and Goppelt-Struebe 2009). Although CCN2 is dispensible for normal cutaneous tissue repair kinetics, CCN2 is responsible for the recruitment and differentiation of progenitor cells into myofibroblasts (Liu et al. 2014; Tsang and Leask 2014). CCN2 is overexpressed in fibrotic disease including diabetes, and is believed to contribute to the kidney and eye fibrosis observed in this disorder (Mason 2009; Klaassen et al. 2015). However, the role of CCN2 in diabetic wounds is unknown. In a recent study from the Twigg laboratory (Henshaw et al. 2015), Sprague–Dawley rats were made diabetic using streptozotocin and subjected to dermal wounding. Wounds in diabetic rats closed more slowly than those in control rats. Wounds in diabetic rats treated with recombinant CCN2 showed enhanced closure; CCN2 had no effect on control wounds. Diabetic wounds showed reduced levels of type IV collagen (which assists in repithelialization) and a-smooth muscle actin and CCN2 treatment somewhat alleviated this phenotype. CCN2 treatment of diabetic mice trended higher α-SMA staining score in fibroblasts and endothelial cells compared with scores in untreated diabetic rats although this did not reach statistical significance. Macrophage number was increased in CCN2-treated wounds, but this result did not achieve statistical significance, Young’s modulus was increased by in animals that were treated with CCN2 compared to untreated control and diabetic mice. Thus, although CCN2 promoted closure of diabetic wounds, only a few parameters were affected in a statistically significant fashion. Perhaps CCN2 might work with other matricellular proteins to promote closure of diabetic wounds.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».