Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation
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Dossier post-publication
- Nature
- Retraction
- Motif
- Concerns/Issues about Data;Duplication of/in Image;Objections by Third Party;Original Data and/or Images not Provided and/or not Available;
- Date
- 4/14/2022 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
UNLABELLED: Since gastrointestinal mucosa is constantly exposed to reactive oxygen species from various sources, the presence of antioxidants may contribute to the body's natural defenses against inflammatory diseases. HYPOTHESIS: To define the polyphenols extracted from dried apple peels (DAPP) and determine their antioxidant and anti-inflammatory potential in the intestine. Caco-2/15 cells were used to study the role of DAPP preventive actions against oxidative stress (OxS) and inflammation induced by iron-ascorbate (Fe/Asc) and lipopolysaccharide (LPS), respectively. RESULTS: The combination of HPLC with fluorescence detection, HPLC-ESI-MS TOF and UPLC-ESI-MS/MS QQQ allowed us to characterize the phenolic compounds present in the DAPP (phenolic acids, flavonol glycosides, flavan-3-ols, procyanidins). The addition of Fe/Asc to Caco-2/15 cells induced OxS as demonstrated by the rise in malondialdehyde, depletion of n-3 polyunsaturated fatty acids, and alterations in the activity of endogenous antioxidants (SOD, GPx, G-Red). However, preincubation with DAPP prevented Fe/Asc-mediated lipid peroxidation and counteracted LPS-mediated inflammation as evidenced by the down-regulation of cytokines (TNF-α and IL-6), and prostaglandin E2. The mechanisms of action triggered by DAPP induced also a down-regulation of cyclooxygenase-2 and nuclear factor-κB, respectively. These actions were accompanied by the induction of Nrf2 (orchestrating cellular antioxidant defenses and maintaining redox homeostasis), and PGC-1α (the "master controller" of mitochondrial biogenesis). CONCLUSION: Our findings provide evidence of the capacity of DAPP to reduce OxS and inflammation, two pivotal processes involved in inflammatory bowel diseases.
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La notice
- Revue
- PLoS ONE
- Thématique
- Phytochemicals and Antioxidant Activities
- Domaine
- Medicine
- Établissements canadiens
- Université LavalCentre Hospitalier Universitaire Sainte-JustineUniversité de Montréal
- Organismes subventionnaires
- —
- Mots-clés
- Oxidative stressInflammationPolyphenolChemistryOxidative phosphorylationBiologyBiochemistryAntioxidantImmunology
- Résumé présent dans OpenAlex
- oui