Gene Study Reveals Clues to Bipolar Disorder Physiology
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
Back to table of contents Previous article Next article Clinical & Research NewsFull AccessGene Study Reveals Clues to Bipolar Disorder PhysiologyJun YanJun YanSearch for more papers by this authorPublished Online:3 Oct 2008https://doi.org/10.1176/pn.43.19.0018aA large genomic study suggests that defective sodium and calcium channels in neurons may explain an important part of the physiological mechanism of bipolar disorder.A group of researchers in the United States, United Kingdom, and Canada found significant association between bipolar disorder and genetic variations in two genes involved in the formation of a sodium channel and a calcium channel, ANK3 and CACNA1C.The study, the largest genomic study on bipolar disorder to date, tested 1.8 million genetic polymorphisms in 4,387 bipolar patients and 6,209 control subjects from three studies to identify genetic variations that may be significantly associated with the illness.Sodium and calcium channels are “ion gates” made of proteins embedded in cell membranes. They regulate the amount of electrically charged sodium and calcium ions flowing in and out of nerve cells as they open and close. This process is a fundamental part of generating and transmitting signals throughout the nervous system.The ANK3 gene is expressed as the ankyrin G protein, a type of protein involved in regulating the sodium channels in nerve cell membranes that open and close according to electrical impulses. They are known as voltage-gated channels because they open and close depending on the difference in electric charges within and outside of the cell membrane. Several single nucleotide polymorphisms across the chromosomal region for the ANK3 gene were found to be strongly associated with bipolar disorder (p=9.1×10-9), meaning that bipolar patients are much more likely to have defects in this protein than those with-out the illness.The second strongest genetic association with the illness was found in a noncoding region (the third intron) of the CACNA1C gene, which codes for a subunit of the L-type voltage-gated calcium channel protein. Additional regions associated with bipolar disorder were also identified.Scientists have already suspected ion channel problems in the mechanism of bipolar disorder, as both ANK3 and subunits of the calcium channel are downregulated in the brain in mice after lithium treatment. The findings in this genomic study have provided strong and independent corroboration for this theory.The study was published online in Nature Genetics on August 17 and supported by grants from a number of government agencies in the United States, Australia, the United Kingdom, and Ireland and several private sources.An abstract of “Collaborative Genome-wide Association Analysis Supports a Role for ANK3 and CACNA1C in Bipolar Disorder” is posted at<www.nature.com/ng/journal/v40/n9/abs/ng.209.html>.▪ ISSUES NewArchived
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle