Microwave open-ended coaxial dielectric probe: interpretation of the sensing volume re-visited
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Notice bibliographique
Résumé
BACKGROUND: Tissue dielectric properties are specific to physiological changes and consequently have been pursued as imaging biomarkers of cancer and other pathological disorders. However, a recent study (Phys Med Biol 52:2637-2656, 2007; Phys Med Biol 52:6093-6115, 2007), which utilized open-ended dielectric probing techniques and a previously established sensing volume, reported that the dielectric property contrast may only be 10% or less between breast cancer and normal fibroglandular tissue whereas earlier data suggested ratios of 4:1 and higher may exist. Questions about the sensing volume of this probe relative to the amount of tissue interrogated raise the distinct possibility that the conclusions drawn from that study may have been over interpreted. METHODS: We performed open-ended dielectric probe measurements in two-layer compositions consisting of a background liquid and a planar piece of Teflon that was translated to predetermined distances away from the probe tip to assess the degree to which the probe produced property estimates representative of the compositional averages of the dielectric properties of the two materials resident within a small sensing volume around the tip of the probe. RESULTS: When Teflon was in contact with the probe, the measured properties were essentially those of pure Teflon whereas the properties were nearly identical to those of the intervening liquid when the Teflon was located more than 2 mm from the probe tip. However, when the Teflon was moved closer to the probe tip, the dielectric property measurements were not linearly related to the compositional fraction of the two materials, but reflected nearly 50% of those of the intervening liquid at separation distances as small as 0.2 mm, and approximately 90% of the liquid when the Teflon was located 0.5 mm from the probe tip. CONCLUSION: These results suggest that the measurement methods reported in the most recent breast tissue dielectric property study are not likely to return the compositional averages of the breast tissue specimens evaluated, and thus, the conclusions reached about the expected dielectric property contrast in breast cancer from this specimen study may not be correct.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle