Can Nitric Oxide-Releasing Hybrid Drugs Alleviate Adverse Cardiovascular Risks?
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Résumé
Future Medicinal ChemistryVol. 5, No. 4 OpinionCan nitric oxide-releasing hybrid drugs alleviate adverse cardiovascular risks?Atul Bhardwaj, Jatinder Kaur & Edward E KnausAtul Bhardwaj* Author for correspondenceFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada Department of Oncology, University of Alberta, Edmonton, AB, Canada. , Jatinder KaurFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada Department of Oncology, University of Alberta, Edmonton, AB, Canada & Edward E KnausFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, CanadaPublished Online:15 Mar 2013https://doi.org/10.4155/fmc.13.23AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: cardiovascular riskCOXdiabetesendothelial dysfunctioninflammationnitric oxideReferences1 Grundy SM, Benjamin IJ, Burke GL et al. 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An update on hybrid drugs in cardiovascular drug research. Expert Opin. Drug. Discov.3(12),1397–1408 (2008).Crossref, Medline, CAS, Google Scholar18 Kaur J, Bhardwaj A, Huang Z et al. Synthesis and biological investigations of nitric oxide releasing nateglinide and meglitinide Type 2 antidiabetic prodrugs: in vivo antihyperglycemic activities and blood pressure lowering studies. J. Med. Chem.55,7883–7891 (2012).Crossref, Medline, CAS, Google Scholar19 Bhardwaj A, Huang Z, Kaur J, Knaus EE. Rofecoxib analogues possessing a nitric oxide donor sulfohydroxamic acid (SO2NHOH) cyclooxygenase-2 pharmacophore: synthesis, molecular modeling, and biological evaluation as anti-inflammatory agents. ChemMedChem7,62–67 (2012).Crossref, Medline, CAS, Google Scholar20 Bhardwaj A, Batchu SN, Kaur J, Huang Z, Seubert JM, Knaus EE. Cardiovascular properties of a nitric oxide releasing rofecoxib analog: beneficial antihypertensive activity and enhanced recovery in an ischemic reperfusion injury model. 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Chem.38,441–446 (2003).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByTadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failureLife Sciences, Vol. 289Synthesis and Biological Evaluation of 1,3,5‐Trisubstituted 2‐Pyrazolines as Novel Cyclooxygenase‐2 Inhibitors with Antiproliferative Activity23 February 2021 | Chemistry & Biodiversity, Vol. 18, No. 3PDE5 inhibitor sildenafil in the treatment of heart failure: A meta-analysis of randomized controlled trialsInternational Journal of Cardiology, Vol. 172, No. 3The importance of drug discovery for treatment of cardiovascular diseasesCharles Kennedy15 March 2013 | Future Medicinal Chemistry, Vol. 5, No. 4 Vol. 5, No. 4 STAY CONNECTED Metrics Downloaded 104 times History Published online 15 March 2013 Published in print March 2013 Information© Future Science LtdKeywordscardiovascular riskCOXdiabetesendothelial dysfunctioninflammationnitric oxideAcknowledgementsA Bhardwaj and J Kaur are grateful to P Singh from Guru Nanak Dev University, Amritsar, India and S Verma form the Indian Institute of Technology, Kanpur, India, for their valuable suggestions and support. A Bhardwaj and J Kaur are also thankful to F Wuest from the Department of Oncology, University of Alberta, Canada, for postdoctoral Fellowship and guidance.Financial & competing interests disclosureThe authors are grateful to the Canadian Institutes of Health Research (grant no. MOP-14712) for financial support of this research. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle