1825 OBESOGENIC PROFILE OF CONTEMPORARY NORTH AMERICAN RENAL STONE PATIENTS
Notice bibliographique
Résumé
You have accessJournal of UrologyStone Disease: New Technology/SWL, Ureteroscopic or Percutaneous Stone Removal1 Apr 20111825 OBESOGENIC PROFILE OF CONTEMPORARY NORTH AMERICAN RENAL STONE PATIENTS Anatoly Shuster, Christopher B. Allard, Ayman Raees, Michael Patlas, Edward D. Matsumoto, Jehonathan H. Pinthus, and J. Paul Whelan Anatoly ShusterAnatoly Shuster Hamilton, Canada More articles by this author , Christopher B. AllardChristopher B. Allard Hamilton, Canada More articles by this author , Ayman RaeesAyman Raees Hamilton, Canada More articles by this author , Michael PatlasMichael Patlas Hamilton, Canada More articles by this author , Edward D. MatsumotoEdward D. Matsumoto Hamilton, Canada More articles by this author , Jehonathan H. PinthusJehonathan H. Pinthus Hamilton, Canada More articles by this author , and J. Paul WhelanJ. Paul Whelan Hamilton, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1844AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Obesity is linked to increased rates of renal stone (RS) formation and treatment failures, and is usually defined according to body mass index (BMI). BMI has inherent limitations as a measure of obesity and fails to account for fat distribution, a more accurate predictor of morbidity. Patterns of fat distribution may affect the success of extracorporeal shockwave lithotripsy (ESWL), since peripheral adipose tissue increases the skin-to-stone distance more than does visceral adipose tissue (VAT). The objective of this study was to characterize the fat distribution and metabolic hormonal milieu in a cohort of RS patients. METHODS 113 patients (73 male; 40 female; mean age 54 years) undergoing treatment for RS between November 2009 and June 2010 at one center were prospectively enrolled; 81 met inclusion for BMI analysis and 63 for %VAT. CT scans were analyzed for visceral and subcutaneous adipose tissue volumes from axial slices at 3 fixed levels (L2 vertebral body, umbilicus and anterior superior iliac spine) using commercial software (Clear Image Demo). Adipose tissue was defined as -250 to -30 Hounsfield Units. The ratio of visceral to total adipose tissue (%VAT) was calculated and BMI data collected. Adiponectin and leptin levels of fasting serum samples were measured by ELISA. RESULTS 28% of patients had BMI within the normal range (<25kg/m2), while 32% were overweight (25 35kg/m2). Mean BMI was 30kg/m2. 54% of females and 32% of males were obese or morbidly obese (BMI>30kg/m2). Mean %VAT was 47.7 and 29.7 for males and females respectively (p<0.001), indicating relatively higher visceral adiposity in males, and peripheral adiposity in females. Mean levels of adiponectin and leptin were 7.67 and 17.50 respectively (normal values are 10ìg/ml and 10 ng/ml respectively). CONCLUSIONS In this cohort of RS patients, males had a higher proportion of visceral adiposity than females (%VAT 47.7 vs. 29.7), while more females were obese or morbidly obese according to BMI. The gender differences in fat distribution may affect ESWL success; obese females have more peripheral adiposity, increasing the skin-to-stone distance and, consequently, the probability of ESWL failure. Mean serum levels of adiponectin and leptin indicate that these RS patients are at risk of obesity-related metabolic disorders and higher perioperative complication rates. These associations should be further investigated in a larger multi-center cohort. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185 Issue 4S April 2011 Page: e732 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Metrics Author Information Anatoly Shuster Hamilton, Canada More articles by this author Christopher B. Allard Hamilton, Canada More articles by this author Ayman Raees Hamilton, Canada More articles by this author Michael Patlas Hamilton, Canada More articles by this author Edward D. Matsumoto Hamilton, Canada More articles by this author Jehonathan H. Pinthus Hamilton, Canada More articles by this author J. Paul Whelan Hamilton, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».