Notice bibliographique
Résumé
<h3>Background</h3> The role and the significance of calcium crystals (CC) in synovial inflammation and in Osteoarthritis (OA) progression is somewhat debated. Calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) are the most common CC in OA. <h3>Objectives</h3> The aim of this study was to evaluate the presence of CC in synovial fluid (SF) using ultrasensitive analysis by scanning electron microscopy (SEM) in the various stages of symptomatic and radiographic knee OA (KOA). <h3>Methods</h3> One hundred twenty consecutive outpatients with KOA underwent knee arthrocentesis. Of these, 49 (40.8%) were in an early stage (<1 year). The SF samples were analyzed by compensated polarized light microscopy and SEM. Patients9 medical history, clinical features, Kellgren Lawrence radiological score (KLRS), ultrasound power Doppler (USPD) signal were assessed. The Western Ontario and McMaster Universities OA Index (WOMAC) self-assessment questionnaire, the Lequesne algofunctional index (Lequesne) survey, and the visual analogic scale (VAS) forms were assessed in all patients. All the patients gave written informed consent. <h3>Results</h3> CC were detected by SEM in 62/120 (51.6%) samples. The patients positive to CC (CC+) were older (p=0.036), had a greater difficulty in moving (p=0.0041), a higher SF PMN percentage (0.0041) and a higher USPD (p≤0.0001) with respect to the group of patients negative to CC (CC-). CPP crystals were positive in 37/120 patients (30%) by SEM. Age (p=0.0002), disease duration (p=0.041), pain (p=0.039), KLRS (p=0.0334) and USPD (p=0.0001) were significant different in the 2 groups of patients subdivided by the presence of CPP. BCP were detected in 33/120 patients (27.5%) by SEM. Subdividing patients by the presence of BCP, we found a significant differences as regard WOMAC (p=0.0001), pain (p=0.0001), stiffness (p<0.0001), functional impairment (p<0.0001), Lequesne index (p<0.0001), VAS (<0.0004) and USPD (p<0.0001). A correlation between KLRS and disease duration (DD) was found in the BCP+ group. The patients were then subdivided into three groups according to DD: I <1yr (N.49) early KOA; II 1-5 yrs (N.27); III >5 yrs (N.44) late KOA. Univariate analysis highlighted a significant difference in age and USPD. In the I group, patients BCP+ significant differences were found in pain (p=0.0002), stiffness (p=0.045), functional impairment (p=0.0014), WOMAC (p=0.0002) and USPD (p=0.0009), all higher with respect to patients negative to BCP. (Figure 1a, b, c) <h3>Conclusions</h3> The presence of CC was found to be correlated with a more severe clinical status, worse imaging findings, and positive USPD. The presence of BCP crystals in the early KOA group, which was associated to inflammatory aspects, suggests a possible role of BCP crystals in the pathogenesis of the disease. <h3>References</h3> Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249-57 Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Osteoarthritis Cartilage.2013;21:16-21 Rosenthal AK. Crystals, inflammation, and osteoarthritis. Curr Opin Rheumatol.2011;23:170-3 <h3>Disclosure of Interest</h3> None declared
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».