Abstract 2201: Long-term risk of colorectal cancer in patients with sessile serrated adenomas, traditional serrated adenomas, and hyperplastic polyps
Notice bibliographique
Résumé
Abstract Evidence for the recently recognized serrated pathway to colorectal cancer (CRCa) is based largely on the similarity of genetic changes in CpG island methylator phenotype positive (CIMP+) cancers and serrated lesions such as the sessile serrated adenoma (SSA). There is limited evidence regarding the future cancer risks in patients diagnosed with these lesions. Methods: We used Danish medical databases to select subjects for a population-based case-control study of CRCa within the population of 272,342 individuals who underwent colonoscopy during 1977 - 2009. 2,045 CRCa cases were diagnosed during 1977-2006. We used risk set sampling to select 8,105 controls matched by gender and year of birth to the cases. After accessing records of colorectal polyps identified in the subjects, we requested histopathological blocks for the first lesions diagnosed as hyperplastic polyps (HPs) at or after the first colonoscopy during the study period, and obtained them for 895 (97%) of the affected subjects. Four expert pathologists used current criteria to review these lesions and reclassify them as SSAs, traditional serrated adenomas (TSAs) or hyperplastic polyps (HPs). Lesions initially diagnosed as conventional adenomas (CADs) were not reviewed, nor were later polyps. We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence limits (CIs) for CRCa associated with polyp types at the first examination recorded with HPs, using patients with no polyp history during the study period as the referent group and adjusting for age and year at first colonoscopy. Results: After review, 48 (2.3%) cases and 81 (1.0%) controls had SSAs but no CADs or TSAs (OR for CRCa = 3.34, 95% CI: 2.31-4.83). TSAs conferred a similarly high CRCa risk (OR = 3.35, 95%CI: 1.39-8.07), but HPs did not (OR = 1.30, 95% CI: 0.96-1.77). The OR for CADs without SSA or TSA was 2.49 (95% CI: 2.23-2.79); subjects with both SSAs and CADs had an OR intermediate between those for CADs alone and SSAs alone. Women with SSAs and no CADs had a higher OR (4.92; 95% CI: 2.96-8.18) than men (OR = 2.18, 95% CI: 1.24-3.82). Proximal SSAs were associated with a particularly high OR (12.39, 95% CI: 4.87-31.51). Consideration of reported metachronous lesions changed most of these ORs only modestly. Conclusions: We found that SSAs and TSAs are associated with a substantial increase in the risk of CRCa. These data provide further evidence for the serrated pathway to CRCa, with SSAs and TSAs as cancer precursors. Citation Format: John A. Baron, Rune Erichsen, Stephen J. Hamilton-Dutoit, Dale C. Snover, Emina E. Torlakovic, Trine Frøslev, Lars Pedersen, Mogens Vyberg, Stanley R. Hamilton, Henrik T. Sørensen. Long-term risk of colorectal cancer in patients with sessile serrated adenomas, traditional serrated adenomas, and hyperplastic polyps. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2201. doi:10.1158/1538-7445.AM2014-2201
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».