P3D-3 Transmission Ultrasound Imaging to Guide Thermal Therapy
Notice bibliographique
Résumé
Minimally Invasive Thermal Therapy (MITT) is an effective way to destroy diseased tissue and could replace surgery, chemotherapy or radiation. During MITT, temperatures in the range of 55-95degC are produced locally, resulting in tissue coagulation. A real-time imaging method is required to prevent damage to the nearby normal tissue during heating and to visualize the changes in size and shape of the diseased tissue. It is known that acoustic attenuation is sensitive to both the tissue temperature and the structural changes during thermal therapy. This work examines the potential of ultrasound attenuation imaging during MITT to quantitatively monitor lesion formation dynamics. A transmission ultrasound camera (AcoustoCam, Imperium Inc., Silver Spring, MD) was used to collect acoustic images. The AcoustoCam was initially calibrated using a set of 10 PVCP (Polyvinyl Chloride Plastisol) tissue-mimicking phantoms. The attenuation values were measured by an insertion technique and found to be in the range of 2.18-26.46 dB at a frequency of 4.76 MHz. The 8 bit mean pixel intensity displayed on the screen, and 14 bit mean pixel intensity from the camera's sensor were extracted. A laser fiber (2 cm long cylindrical diffuser, Photoglow, Yarmouth, MA) was used to locally heat albumen temperature- sensitive phantoms and bovine liver tissue. The 8 bit mean pixel intensity as well as temperature were recorded for the heating and cooling periods every two seconds in a region close to the laser fiber. The relationship between the AcoustoCam mean pixel intensity and acoustic attenuation was established. Heating the agar-albumen phantoms and bovine liver tissue increased the local temperature and resulted in an ellipsoidal lesion. In all heating experiments an initial rapid attenuation decrease at low temperatures was followed by a gradual increase in attenuation as temperature increased. During the cooling procedure, attenuation increased rapidly until it reached a steady state, and remained at an attenuation value greater than the value when no thermal lesion was present within the sample. The initial attenuation decrease and the final attenuation increase are reversible and are hypothesized to be a temperature effect, while the gradual change in attenuation at higher temperatures is assumed to be due to protein coagulation. In summary, it was shown that the acoustic camera could monitor in real time the dynamics of lesion formation and that the attenuation profile during heating follows a reproducible pattern.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».