Endocrine Effects of Brain Serotonin Depletion by 5,6-Dihydroxytryptamine in Prepuberal Male Rats
Notice bibliographique
Résumé
The effects of selective degeneration of brainserotoninergic nerve terminals by 5,6-dihydroxytryptamine (5,6-DHT) injected intraventricularly in prepuberal male rats were studied in 2 experiments. In both experiments, male Sprague-Dawley rats were injected in a lateral ventricle of the brain at 21 and 23 days of age with either 5,6-DHT or vehicle, and autopsied 1,2 and 4 weeks after the 1st injection. Controls were either pair-fed or fed ad lib. In the first experiment the effects of 5,6-DHT on body and organ growth and pituitary levels of radioimmunoassayable growth hormone (GH) were studied. In the second experiment the effects of 5,6-DHT on plasma and pituitary levels of radioimmunoassayable follicle-stimulating hormone (FSH) were studied. Histological examinations of the testes obtained at 4 weeks were performed. Experimental animals on the whole ate 41.8 % less food than controls fed ad lib. The analysis of variance showed that experimental animals, when compared with pair-fed controls, had significantly lower brain 5-HT levels (as measured by spectrophotofluoro-metry) at 1 and 2 weeks, significantly lower body weights at 1 week, and significantly smaller tails at 1 and 2 weeks after the first injection. Brain weights of experimental rats were significantly lower than those of controls fed ad lib. at 2 and 4 weeks; those of pair-fed animals, although lower at 2 weeks, were not significantly different from brain weights of controls fed ad lib. at 4 weeks. At 4 weeks, testes weights (corrected for body weights) were significantly lower in experimental rats than in controls fed ad lib. At 2 weeks, both the experimental and the pair-fed group had pituitary GH levels (corrected for body weights) lower than those of the group fed ad lib. Plasma FSH levels were undetectable at 1 week both in experimental and pair-fed animals. Pituitary FSH concentration was significantly reduced at 2 weeks and significantly increased at 4 weeks in the experimental rats when compared with the controls fed ad lib. Histological examination of the testes showed that controls fed ad lib. and pair-fed had reached full spermatogenesis at 4 weeks after the 1st injection (51 days of age); spermatogenesis of experimental animals was usually blocked at the stage of pachytene spermatocytes. In conclusion, depletion of brain 5-HT inhibited body and brain growth and sexual maturation partly through the ensuing anorexia and malnutrition, but possibly also through a specific decrease in synthesis and/or secretion of GH and FSH.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».