Endocrine Effects of Brain Serotonin Depletion by 5,6-Dihydroxytryptamine in Prepuberal Male Rats
Notice bibliographique
Résumé
The effects of selective degeneration of brainserotoninergic nerve terminals by 5,6-dihydroxytryptamine (5,6-DHT) injected intraventricularly in prepuberal male rats were studied in 2 experiments. In both experiments, male Sprague-Dawley rats were injected in a lateral ventricle of the brain at 21 and 23 days of age with either 5,6-DHT or vehicle, and autopsied 1,2 and 4 weeks after the 1st injection. Controls were either pair-fed or fed ad lib. In the first experiment the effects of 5,6-DHT on body and organ growth and pituitary levels of radioimmunoassayable growth hormone (GH) were studied. In the second experiment the effects of 5,6-DHT on plasma and pituitary levels of radioimmunoassayable follicle-stimulating hormone (FSH) were studied. Histological examinations of the testes obtained at 4 weeks were performed. Experimental animals on the whole ate 41.8 % less food than controls fed ad lib. The analysis of variance showed that experimental animals, when compared with pair-fed controls, had significantly lower brain 5-HT levels (as measured by spectrophotofluoro-metry) at 1 and 2 weeks, significantly lower body weights at 1 week, and significantly smaller tails at 1 and 2 weeks after the first injection. Brain weights of experimental rats were significantly lower than those of controls fed ad lib. at 2 and 4 weeks; those of pair-fed animals, although lower at 2 weeks, were not significantly different from brain weights of controls fed ad lib. at 4 weeks. At 4 weeks, testes weights (corrected for body weights) were significantly lower in experimental rats than in controls fed ad lib. At 2 weeks, both the experimental and the pair-fed group had pituitary GH levels (corrected for body weights) lower than those of the group fed ad lib. Plasma FSH levels were undetectable at 1 week both in experimental and pair-fed animals. Pituitary FSH concentration was significantly reduced at 2 weeks and significantly increased at 4 weeks in the experimental rats when compared with the controls fed ad lib. Histological examination of the testes showed that controls fed ad lib. and pair-fed had reached full spermatogenesis at 4 weeks after the 1st injection (51 days of age); spermatogenesis of experimental animals was usually blocked at the stage of pachytene spermatocytes. In conclusion, depletion of brain 5-HT inhibited body and brain growth and sexual maturation partly through the ensuing anorexia and malnutrition, but possibly also through a specific decrease in synthesis and/or secretion of GH and FSH.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».