Novel Aspects of Nonfasting Lipemia in relation to Vascular Biology
Notice bibliographique
Résumé
Several cardiovascular risk factors have been described during the last decades. Postprandial hyperlipidemia has been recognized as an important factor contributing to atherogenesis; however chylomicron remnants have not been used widely in risk equations. One of the probable causes for this lack of consideration in clinical practice may be that the metabolism of chylomicrons and their remnants has been rather difficult to study and, more so, to modulate in vivo. The current issue of the International Journal of Vascular Medicine provides novel insight into the metabolic changes of chylomicrons and their remnants in relation to vascular damage. The paper by G. H. Tomkin and D. Owens “The chylomicron: relationship to atherosclerosis” provides an excellent overview of the molecular mechanisms involved in chylomicron synthesis and metabolism in humans. The paper by B. Klop et al. “Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases” describes novel aspects related to inflammation in different clinical conditions and under variable lifestyle situations. Following this line of inflammatory-dependent aspects of chylomicrons, the paper by M. Cao et al. “Dual AAV/IL-10 plus STAT3 anti-inflammatory gene delivery lowers atherosclerosis in LDLR KO mice, but without increased benefit” further explores aspects of cholesterol metabolism involving different molecular targets important for both hepatic and intestinal cholesterol metabolism. S. A. Lopez et al. proceed with a paper investigating the effects of oxidized chylomicron remnants on monocyte activation and the effects of the antioxidant drug probucol on this interaction “The oxidative state of chylomicron remnants influences their modulation of human monocyte activation.” L. D. Roche and et al. provide evidence suggesting that postprandial hypertriglyceridemia simulated by an infusion with artificial TG-rich lipoproteins (Lipofundin) induces oxidative stress and atherosclerotic lesions in an animal model prone to develop atherosclerosis “Lipofundin-induced hyperlipidemia promotes oxidative stress and atherosclerotic lesions in New Zealand white rabbits.” The paper by M. Napolitano et al. “Phospholipase A2 mediates apolipoprotein-independent uptake of chylomicron remnant-like particles by human macrophages” includes novel work showing that macrophage lipolytic enzymes mediate the internalization of postprandial TG-rich lipoproteins and that secretory phospholipase A2 (sPLA2) and cytosolic PLA2 play a more important role than extracellular lipoprotein lipase-mediated TG hydrolysis. M. M. Pallebage-Gamarallage et al. describe in the following investigation “A diet enriched in docosahexanoic acid exacerbates brain parenchymal extravasation of Apo B lipoproteins induced by chronic ingestion of saturated fats,” how dietary interventions can lead to modulation of cerebrovascular inflammation by oxidative stress. A. Van der Wiel provides a comprehensive update on the effects of alcohol ingestion on fasting and postprandial triglyceridemia “The effect of alcohol on postprandial and fasting triglycerides”, which is followed by a paper by B. Klop et al. “AT1 receptor gene polymorphisms in relation to postprandial lipemia” showing a novel relationship between polymorphisms of genes involved in the regulation of blood pressure with postprandial lipemia. J. P. H. van Wijk and M. Castro Cabezas contributed with an update on the effects of antiretroviral therapy in HIV-infected patients on TG metabolism “Hypertriglyceridemia, metabolic syndrome, and cardiovascular disease in HIV-infected patients: effects of antiretroviral therapy and adipose tissue distribution.” Finally, G. Charach et al. provided a review describing the effects of bile acid secretion and intestinal absorption on plasma lipoproteins and coronary atherosclerosis. M. Castro Cabezas Kathleen M. Botham John C. L. Mamo Spencer D. Proctor
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,002 | 0,002 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».