Long-Term Deterioration of Kidney Allograft Function
Notice bibliographique
Résumé
Although long-term survival after kidney transplanta-tion is critically dependent on maintaining stable al-lograft function, few studies have examined renal al-lograft function over time. Using pooled data from 10 278 consecutive transplants at five centers, we cal-culated slopes of estimated glomerular filtration rates (eGFR) measured after 1, 6 and 12 months in 9515, 8861 and 7359 patients surviving ≥1, ≥6 and ≥12 months, respectively. Slopes of eGFR progressively di-minished for patients transplanted during 1984–1989, 1990–1993,1994–1998 and 1999–2002 (analysis of vari-ance p < 0.0001 and p = 0.1245 for slopes measured after 1 and 6 months, respectively). Slopes measured after 12 months were less in the most recent era: –2.2 ± 7.2 mL/min/1.73 m2/year, –2.3 ± 6.6 mL/min/1.73 m2/year, –2.4 ± 7.4 mL/min/1.73 m2/year and –1.4 ± 10.9 mL/min/1.73 m2/year, respectively, p = 0.0058. Slopes measured after 1, 6 and 12 months each were less for transplantations during 1999–2002, after adjusting for multiple transplantation characteristics (p < 0.0001). Similarly, in Cox proportional hazards analysis, the risk (95% CI) for a 25% reduction in eGFR was 0.92 (0.85–1.01), p = 0.0736 during 1990–1994; 0.94 (0.82–1.08), p = 0.4111 during 19951998 and 0.78 (0.64–0.95), p = 0.0110 during 1999–2002 (compared to 1984–1989). We conclude that the rate of decline in allograft function after kidney transplantation has improved, suggesting that stable, long-term function may be achievable. Although long-term survival after kidney transplanta-tion is critically dependent on maintaining stable al-lograft function, few studies have examined renal al-lograft function over time. Using pooled data from 10 278 consecutive transplants at five centers, we cal-culated slopes of estimated glomerular filtration rates (eGFR) measured after 1, 6 and 12 months in 9515, 8861 and 7359 patients surviving ≥1, ≥6 and ≥12 months, respectively. Slopes of eGFR progressively di-minished for patients transplanted during 1984–1989, 1990–1993,1994–1998 and 1999–2002 (analysis of vari-ance p < 0.0001 and p = 0.1245 for slopes measured after 1 and 6 months, respectively). Slopes measured after 12 months were less in the most recent era: –2.2 ± 7.2 mL/min/1.73 m2/year, –2.3 ± 6.6 mL/min/1.73 m2/year, –2.4 ± 7.4 mL/min/1.73 m2/year and –1.4 ± 10.9 mL/min/1.73 m2/year, respectively, p = 0.0058. Slopes measured after 1, 6 and 12 months each were less for transplantations during 1999–2002, after adjusting for multiple transplantation characteristics (p < 0.0001). Similarly, in Cox proportional hazards analysis, the risk (95% CI) for a 25% reduction in eGFR was 0.92 (0.85–1.01), p = 0.0736 during 1990–1994; 0.94 (0.82–1.08), p = 0.4111 during 19951998 and 0.78 (0.64–0.95), p = 0.0110 during 1999–2002 (compared to 1984–1989). We conclude that the rate of decline in allograft function after kidney transplantation has improved, suggesting that stable, long-term function may be achievable.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».