Relationship between Resting Pulse Rate and Lipid Metabolic Dysfunctions in Chinese Adults Living in Rural Areas
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Dossier post-publication
- Nature
- Retraction
- Motif
- Concerns/Issues about Data;Investigation by Company/Institution;
- Date
- 4/6/2021 0:00
- Signalé par OpenAlex ?
- Oui
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Résumé
BACKGROUND: Resting pulse rate has been observed to be associated with cardiovascular diseases. However, its association with lipid metabolic dysfunctions remains unclear, especially resting pulse rate as an indicator for identifying the risk of lipid metabolic dysfunctions. The purpose of this study was to examine the association between resting pulse rate and lipid metabolic dysfunctions, and then evaluate the feasibility of resting pulse rate as an indicator for screening the risk of lipid metabolic dysfunctions. METHODS: A cross-sectional survey was performed, and 16,926 subjects were included in this study from rural community residents aged 35-78 years. Resting pulse rate and relevant covariates were collected from a standard questionnaire. The fasting blood samples were collected and measured for lipid profile. Predictive performance was analyzed by receiver operating characteristic (ROC) curve. RESULTS: A significant correlation was observed between resting pulse rate and TC (r = 0.102, P = 0.001), TG (r = 0.182, P = 0.001), and dyslipidemia (r = 0.037, P = 0.008). In the multivariate models, the adjusted odds ratios for hypercholesterolemia (from 1.07 to 1.15), hypertriglyceridemia (1.11 to 1.16), low HDL hypercholesterolemia (1.03 to 1.06), high LDL hypercholesterolemia (0.92 to 1.14), and dyslipidemia (1.04 to 1.07) were positively increased across quartiles of resting pulse rate (P for trend <0.05). The ROC curve indicated that resting pulse rate had low sensitivity (78.95%, 74.18%, 51.54%, 44.39%, and 54.22%), specificity (55.88%, 59.46%, 57.27%, 65.02%, and 60.56%), and the area under ROC curve (0.70, 0.69, 0.54, 0.56, and 0.58) for identifying the risk of hypercholesterolemia, hypertriglyceridemia, low HDL hypercholesterolemia, high LDL hypercholesterolemia, and dyslipidemia, respectively. CONCLUSION: Fast resting pulse rate was associated with a moderate increased risk of lipid metabolic dysfunctions in rural adults. However, resting pulse rate as an indicator has limited potential for screening the risk of lipid metabolic dysfunctions.
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La notice
- Revue
- PLoS ONE
- Thématique
- Heart rate and cardiovascular health
- Domaine
- Medicine
- Établissements canadiens
- Centre Hospitalier Universitaire Sainte-Justine
- Organismes subventionnaires
- China Postdoctoral Science FoundationNational Natural Science Foundation of China
- Mots-clés
- DyslipidemiaMedicineInternal medicineHypertriglyceridemiaBasal metabolic rateLipid profileOdds ratioEndocrinologyCardiologyTriglycerideCholesterolObesity
- Résumé présent dans OpenAlex
- oui