Notice bibliographique
Résumé
Introduction Current monoclonal anti‐D reagents will react with most D‐variant RBCs. A small number of individuals with D variant phenotypes ( e.g. IIIa, IV, V, VI, VII, DAU) appear to be stimulated to produce allo anti‐D more readily than others. DAR is characterised by the complete loss of at least nine of 37 RhD epitopes. We are reporting two cases of allo anti‐D in patients who have the DAR phenotype. Case history Case 1: An African woman aged 20 was admitted for termination of pregnancy with no clinical history available. She was grouped as B, R o . Her D phenotype using BioVue was weakly positive and also with anti‐D reagents RUM1 and MS201 by tube. The antibody screen was positive, and suggestive of anti‐D. Our laboratory found her RBCs strongly positive with RUM1 and MS201 anti‐Ds by tube and with DiaMed grouping cards. The Diagast D‐screen suggested a weak D antigen. No plasma was supplied for antibody identification. A weak anti‐D by tube LISS IAT was detected in a subsequent sample. The D status was identified by IBGRL as DAR. Case 2: A pregnant African female, aged 35 was grouped by the referring hospital as O, D+; the antibody screen was suggestive of anti‐D by Capture R. Our laboratory had tested her D status in Feb. 2003 after a miscarriage. We reported her as weak D with a negative antibody screen. No anti‐D Ig prophylaxis was given. In our laboratory the most recent sample grouped as O, R o . Her RBCs gave strongly positive reactions with RUM1 and MS201 by tube and with DiaMed grouping cards. The Diagast D‐screen suggested weak D. Anti‐D was detected with a level of <0.1 IU mL −1 . The D status was identified by IBGRL as DAR. Conclusion Immunisation risk for DAR is estimated to be >1% per D+ transfusion, which is less than for anti‐K and anti‐c but similar to anti‐Fy a and anti‐Jk a . The incidence of DAR has been reported as one in 4233 from a population with ‘mixed ethnicity’ in Canada. There is no routine serological method to identify all partial D types. In these two cases the D‐screen indicated both were weak D, and the current monoclonal anti‐D typing reagents used gave positive reactions. Although both of the patients were immunised, the anti‐D in both cases was weak which concurs with our previous experience of anti‐D in partial D individuals. Molecular studies may help to provide further information about the likelihood of the risk of immunisation.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».