Whole genome single nucleotide polymorphism associations with feed intake and feed efficiency in beef cattle1
Notice bibliographique
Résumé
Feed intake and efficiency are economically important traits because feed is the greatest variable cost in beef production. Feed efficiency can be measured as residual feed intake (RFI), which is the difference between actual DMI of an animal and the expected DMI based on its BW and growth rate. Feed conversion ratio (FCR) is the inverse of gross feed efficiency and is the ratio of DMI to ADG. A total of 2,633 SNP across the 29 bovine autosomes were analyzed in 464 steers sired by Angus, Charolais, or Alberta Hybrid bulls for associations with RFI. A total of 150 SNP were associated with RFI at P < 0.05 of which 23 were significant at P < 0.01. Nine of the SNP pairs show high linkage disequilibrium (r(2) > 0.80), so only 1 of the SNP pairs was used in further multiple-marker analyses. Two methods were used to create a panel of SNP that were maximally informative for RFI based on the data. In the first method, 141 unique SNP were combined in a single multivariate model and a backward elimination model was used to drop SNP until all SNP left in the model were significant at P < 0.05. The SNP had greater effects when combined in the multivariate model than when tested individually. In the second method, the estimates from the 141 SNP were used to create a sequential molecular breeding value (MBV) according to the compound covariate prediction (CCP) procedure. The sequential MBV was built by adding the estimated effects one at a time, but only keeping SNP effects in the sequential MBV if the test statistic and the proportion of variance explained were improved. Predictabilities of the 2 methods were compared by regressing RFI on a final MBV created from SNP that remained in each analytical model. The MBV from the compound covariate prediction model produced an r(2) of 0.497, whereas the multivariate model MBV had a decreased r(2) of 0.416. The significant SNP were also tested for associations with DMI and FCR. The SNP showed different combinations of associations with the 4 traits, including some that were only associated with RFI. About 9.5% of the SNP from the 2 models were within 5 cM of previously identified RFI QTL and pinpoint areas to further explore for positional candidate genes. In conclusion, this study has identified a panel of SNP with significant effects on RFI that need to be validated in an independent population and provides continued progress toward selecting markers for use in marker-assisted selection for feed efficiency in beef cattle.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».