P1-S2.53 Hepatitis C Virus in men who have sex with men with no history of injection drug use - evidence for sexual transmission? A Canadian perspective
Notice bibliographique
Résumé
Background Sexual transmission of hepatitis C virus (HCV) is not common compared to other modes of transmission such as injection drug use (IDU). There have been recent reports of sexually transmitted HCV outbreaks among men who have sex with men (MSM) in Europe. The present analysis examines the Canadian HCV seroprevalence in MSM with no reported history of IDU. Methods Data from Phase 1 of M-Track (2005−2007), a national enhanced surveillance system of HIV and other sexually transmitted and blood-borne infections (STBBI) and associated risk behaviours among MSM in Canada, were analysed. HCV and HIV status were ascertained using serology tests on dried blood spot (DBS) specimens, and risk factors were assessed via self-administered questionnaire. Bivariate analyses using χ2 tests and ORs with 95% CIs were performed. Results Overall (regardless of IDU history), 5.3% of M-Track participants were seropositive for HCV. Among MSM who did not report any history of IDU (N=3250), HCV seropositivity was 2.1%, and was higher among HIV-infected MSM compared to those who were uninfected (5.1% vs 1.7% respectively, p<0.001). Factors associated with HCV seropositivity among non-IDU are presented in Abstract P1-S2.53 table 1. Being 30 yearss of age or older, having ever received money, drugs, or goods for sex, and use of any recreational drug in the 2 h preceding or during sex (specifically heroin/opioids, marijuana, tranquilisers, or cocaine) were all positively associated with being seropositive for HCV. Asbtract P1-S2.53 Table 1 Self-reported factors associated with HCV seropositivity among MSM with no self-reported history of IDU, M-Track Phase 1 (2005−2007) Risk factor HCV positive N (%) Univariate OR (95% CI) p value Age (N=2167) 29 or less (Ref) 2 (0.4) 5.5 (1.3 to 22.8) 0.015 30 and up 38 (2.2) Number of male anal sex partners in past 6 months (N=1342) One (Ref) 5 (1.1) 1.5 (0.6 to 4.2) 0.408 Two or more 15 (1.7) HIV seroconcordant unprotected anal intercourse (“serosorting”) (N=2136) No (Ref) 30 (1.9) 0.6 (0.3 to 1.5) 0.266 Yes 6 (1.1) Ever received money, goods, or drugs for sex (N=2534) No (Ref) 30 (1.3) 8.2 (4.6 to 14.5) <0.001 Yes 21 (9.7) Ever used recreational drugs within 2 h of sex (N=2536) No (Ref)Yes 32 (1.6)17 (3.4) 2.2 (1.2 to 4.0) 0.008 Ever used heroin/opioids within 2 h of sex (N=2521) No (Ref) 42 (1.7) 8.5 (3.2 to 22.9) <0.001 Yes 5 (12.8) Ever used alcohol within 2 h of sex (N=2575) No (Ref) 14 (2.1) 0.9 (0.5 to 1.7) 0.729 Yes 35 (1.8) Ever used marijuana within 2 h of sex (N=2539) No (Ref) 19 (1.2) 2.8 (1.6 to 5.1) <0.001 Yes 31(3.3) Ever used tranquilisers within 2 h of sex (N=2518) No (Ref) 46 (1.9) 5.5 (1.6 to 18.7) 0.016 Yes 3 (9.4) Ever used cocaine within 2 h of sex (N=2520) No (Ref) 29 (1.4) 4.1 (2.3 to 7.3) <0.001 Yes 20 (5.3) Ever used sexual enhancers within 2 h of sex (N=2545) No (Ref) 29 (1.8) 1.1 (0.6 to 2.0) 0.671 Yes 19 (2.0) Conclusions These findings do not confirm sexual transmission of HCV given the possibility of unreported IDU or other unknown parenteral transmission risk factors in this sample; however, they do support existing evidence of increased risk of HCV infection among HIV-infected MSM. Interpretation of results is limited by the self-reported nature of behaviours and the inability of laboratory tests used to distinguish between current infection from resolved/treated HCV or acute from chronic HCV status. Furthermore, behaviours reported in the past 6 months may not accurately reflect the risk profile of HCV-seropositive individuals at the time of infection. HCV testing for HIV-infected MSM, even in the absence of an IDU history, may be of benefit.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».