1780 FEMALE GENDER IS ASSOCIATED WITH HIGHER RISK OF DISEASE RECURRENCE IN PATIENTS WITH PRIMARY T1 HIGH GRADE UROTHELIAL CARCINOMA OF THE BLADDER
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You have accessJournal of UrologyBladder Cancer: Superficial (II)1 Apr 20131780 FEMALE GENDER IS ASSOCIATED WITH HIGHER RISK OF DISEASE RECURRENCE IN PATIENTS WITH PRIMARY T1 HIGH GRADE UROTHELIAL CARCINOMA OF THE BLADDER Luis A Kluth, Harun Fajkovic, Evanguelos Xylinas, Joseph J Crivelli, Niccolo Passoni, Morgan Rouprêt, Andreas Becker, Evi Comploj, Armin Pycha, Sten Holmang, Amit Gupta, Pierre I Karakiewicz, Yair Lotan, Paolo Gontero, Felix KH Chun, Douglas S Scherr, and Shahrokh F Shariat Luis A KluthLuis A Kluth New York, NY More articles by this author , Harun FajkovicHarun Fajkovic St. Poelten, Austria More articles by this author , Evanguelos XylinasEvanguelos Xylinas New York, NY More articles by this author , Joseph J CrivelliJoseph J Crivelli New York, NY More articles by this author , Niccolo PassoniNiccolo Passoni Milano, Italy More articles by this author , Morgan RouprêtMorgan Rouprêt New York, NY More articles by this author , Andreas BeckerAndreas Becker Montreal, Canada More articles by this author , Evi ComplojEvi Comploj Bolzano, Italy More articles by this author , Armin PychaArmin Pycha Bolzano, Italy More articles by this author , Sten HolmangSten Holmang Goeteborg, Sweden More articles by this author , Amit GuptaAmit Gupta Iowa City, IA More articles by this author , Pierre I KarakiewiczPierre I Karakiewicz Montreal, Canada More articles by this author , Yair LotanYair Lotan Dallas, TX More articles by this author , Paolo GonteroPaolo Gontero Torino, Italy More articles by this author , Felix KH ChunFelix KH Chun Hamburg, Germany More articles by this author , Douglas S ScherrDouglas S Scherr New York, NY More articles by this author , and Shahrokh F ShariatShahrokh F Shariat New York More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2870AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES An increasing body of evidence suggests that gender impacts the presentation and prognosis of urothelial carcinoma of the bladder (UCB). The aim of this study was to assess the impact of gender on clinical outcomes in a large cohort of patients with clinical primary T1 high grade (HG) UCB. METHODS In this multi-institutional study, we retrospectively analyzed the data from 916 patients with primary T1 HG UCB from 7 centers between 1996 and 2007. Patients were treated with transurethral resection of the bladder with or without intravesical instillation therapy (IVT). Univariable and multivariable cox regression analyses assessed the effect of gender on outcomes. RESULTS Within a median follow-up of 42.8 months (IQR: 56), 365 (39.8%) patients experienced disease recurrence, 104 (11.4%) progression, 59 (6.4%) cancer-specific death and 190 (20.7%) death of any causes. Overall, 634 (69.2%) patients received IVT of which only 234 (25.5%) patients received BCG therapy. There was no difference between gender with regards to IVT (p=0.36) and age (p=0.45). Female gender (n=190, 20.7%) was associated with higher risk of disease recurrence (HR 1.359; 1.071-1.724, p=0.012) in all 916 patients (Figure 1) and in a subgroup of patients treated with intravesical Bacillus Calmette-Guérin (BCG) therapy (HR1.7; 1.1-2.7, p=0.017). Gender had no impact on disease progression, cancer-specific mortality and all-cause mortality. Tumour size and number of tumours were independent predictors of disease progression (p=0.035 and p=0.002, respectively). The number of tumours was an independent predictor of cancer-specific and all cause mortality (p=0.003 and p<0.001, respectively). In multivariable analyses that adjusted for standard clinico-pathologic factors, gender remained an independent predictor for disease recurrence (p=0.026) when analyzed in all patients, but not in the subgroup of BCG only patients (p=0.09). CONCLUSIONS In patients with T1 HG UCB, female gender is associated with higher risk of disease recurrence, but not with more important endpoints such as progression. This gender disparity may be due to differences in care and/or biology of UCB. Further research is necessary to understand and close the gender gap in UCB prognosis. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e731-e732 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Luis A Kluth New York, NY More articles by this author Harun Fajkovic St. Poelten, Austria More articles by this author Evanguelos Xylinas New York, NY More articles by this author Joseph J Crivelli New York, NY More articles by this author Niccolo Passoni Milano, Italy More articles by this author Morgan Rouprêt New York, NY More articles by this author Andreas Becker Montreal, Canada More articles by this author Evi Comploj Bolzano, Italy More articles by this author Armin Pycha Bolzano, Italy More articles by this author Sten Holmang Goeteborg, Sweden More articles by this author Amit Gupta Iowa City, IA More articles by this author Pierre I Karakiewicz Montreal, Canada More articles by this author Yair Lotan Dallas, TX More articles by this author Paolo Gontero Torino, Italy More articles by this author Felix KH Chun Hamburg, Germany More articles by this author Douglas S Scherr New York, NY More articles by this author Shahrokh F Shariat New York More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».