Is response to IVIG in Chronic Idiopathic Urticaria related to presense of autoantibodies?
Notice bibliographique
Résumé
Treatment of Chronic Idiopathic Urticaria (CIU) may be challenging, as patients can be refractory to various treatments. This may be due to an autoimmune mechanism in its pathogenesis. CIU has been shown to be associated with autoantibodies to IgE or IgE receptor and with thyroid autoimmunity [1,2]. Treatments targeting this autoimmune pathogenesis are now being used, such as intravenous immunoglobulin (IVIG). We reviewed patients with CIU treated with IVIG to see if response to treatment correlated with presence of autoimmunity (antibodies to IgE/IgE receptor or Thyroidperoxidase (TPO) antibodies). A retrospective chart review of patients seen in Allergy and Clinical Immunology clinics at Health Sciences Centre and Grace Hospital in Winnipeg was completed. Inclusion criteria included treatment with IVIG with a clinical diagnosis of CIU. There were a total of 21 patients identified. 13 patients were treated with protocol A, 2g/kg load split between 4 doses given within a two week period followed by maintenance of 0.5 g/kg. Protocol B was used for 8 patients consisting of monthly IVIG (60-80g). Autoimmune blood work was recorded for Histamine Release Assay (HRA) and TPO. HRA testing implies the presence of antibodies to IgE or IgE receptor. Patients' response to IVIG was recorded. HRA was done on 15 /21 patients and 5 of these patients tested positive. 3/5 were able to maintain remission with continued IVIG treatment, one relapsed after discontinuing IVIG following remission and one was unresponsive to IVIG. Anti-TPO was tested in 11 patients of which 3 were positive. Of these three patients, one was responsive to IVIG, one relapsed after initially being responsive and one was unresponsive. Overall 13/21 patients were responsive to IVIG. Of those who were responsive to IVIG 6 were HRA negative and 3 HRA positive of the 9 tested, and 4 TPO negative and 1 TPO positive of the 5 tested for TPO. When comparing protocols, 7/13 patients who underwent protocol A responded without relapse compared to 6/8 treated with protocol B. IVIG can be effective in some patients with CIU who are unresponsive to antihistamine treatment. A greater number of patients who were responsive to IVIG had negative results for the autoimmune tests we conducted. Therefore, based on our data, the response to IVIG cannot be determined by the presence of positive HRA or TPO antibody.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».