Broad targeting of resistance to apoptosis in cancer
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Résumé
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer.
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La notice
- Revue
- Seminars in Cancer Biology
- Thématique
- Cell death mechanisms and regulation
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- —
- Organismes subventionnaires
- National Institute of Neurological Disorders and StrokeNational Institute on Deafness and Other Communication DisordersTerry Fox FoundationNational Institutes of HealthMinistry of Science and Technology, TaiwanNational Cancer InstituteMinistero dell’Istruzione, dell’Università e della RicercaNational Institute on Minority Health and Health DisparitiesNational Center for Research ResourcesTaipei Medical UniversityNational Science CouncilEuropean Cooperation in Science and TechnologyUnited Soybean BoardBarbara Ann Karmanos Cancer InstituteAl Jalila FoundationJackson State University
- Mots-clés
- NecroptosisApoptosisCancerCancer researchCancer cellProgrammed cell deathSignal transductionAutophagyXIAPBiologyCell biologyCaspase
- Résumé présent dans OpenAlex
- oui