Periarticular Hyaluronic Acid in Acute Ankle Sprain
Notice bibliographique
Résumé
OBJECTIVES: To determine the efficacy and safety of periarticular hyaluronic acid injections in acute lateral ankle sprain during 9 months at a sports injuries center. DESIGN: Randomized controlled prospective trial. SETTING: Primary sport medicine and emergency practice. PATIENTS: One hundred fifty-eight consecutive competitive athletes who suffered acute grade 1 or 2 lateral ankle sprains were randomized within 48 hours of injury. INTERVENTIONS: Patients were randomized at baseline to periarticular injection with hyaluronic acid (HA) + standard of care [rest, ice, compression, and elevation (RICE)] or placebo injection (PL) + standard of care (RICE) treatment at baseline assessment and on day 4 after injury. OUTCOMES MEASURES: Assessments at baseline and days 4, 8, 30, and 90 included Visual Analogue Scale (VAS; 0-10 cm) pain on weight bearing and walking 20 m, patient global assessment of ankle injury (five-point categorical scale), patient satisfaction with treatment (five-point categorical scale), time to return to pain-free and disability-free sport, and adverse events. Differences between groups were determined using an intent-to-treat analysis of variance. RESULTS: About 30% of the ankle sprains were "first" events, and no differences in clinical assessments with those presenting but not volunteering for the study (n = 341) were observed. Time to intervention was 39 +/- 4 hours, with no difference between groups. No serious adverse events were recorded during the 8-day treatment period. No difference in concomitant treatment or physical therapy was observed between groups. A significant reduction in VAS pain on both weight bearing and walking was observed at day 8 for HA compared with PL (P < 0.05). Significantly greater patient satisfaction was observed for HA versus PL at days 4 (P < 0.05), 8 (P < 0.001), 30 (P < 0.001), and 90 (P < 0.05). Patient global assessment of ankle injury was significantly better compared with baseline in the HA group at day 8, but this was not different between groups. Time to pain-free and disability-free return to sport was 11 (+/-8) versus 17 (+/-8) days for HA and PL, respectively (P < 0.05). CONCLUSION: HA treatment for acute ankle sprain was highly satisfactory in the short term and the long term versus PL. This was associated with reduced pain and more rapid return to sport, with few associated adverse events.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,009 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».