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Enregistrement W2076151897 · doi:10.1074/jbc.m411520200

Vitamin D Receptor-dependent Regulation of Colon Multidrug Resistance-associated Protein 3 Gene Expression by Bile Acids

2005· article· en· W2076151897 sur OpenAlexaff
Tanya C. McCarthy, Xiufeng Li, Christopher J. Sinal

Notice bibliographique

RevueJournal of Biological Chemistry · 2005
Typearticle
Langueen
DomaineMedicine
ThématiqueDrug Transport and Resistance Mechanisms
Établissements canadiensDalhousie University
Organismes subventionnairesnon disponible
Mots-clésCalcitriol receptorBile acidOrganic anion transporter 1BiologyLithocholic acidRetinoic acidEndocrinologyInternal medicineMolecular biologyBiochemistryTransporterVitamin D and neurologyGeneMedicine

Résumé

récupéré en direct d'OpenAlex

The multidrug resistance-associated protein 3 (MRP3) is a multispecific anion transporter that is capable of transporting a number of conjugated and unconjugated bile acids. Expression of the MRP3 gene is increased during pathological states associated with elevated bile acid concentrations indicating a role transporter and bile acid of with bile the of the the and of a acid and the bile acid a of with a and of the of the of of of with of the gene the of associated with and of the a role the the of bile acid of the The multidrug resistance-associated protein 3 (MRP3) is a multispecific anion transporter that is capable of transporting a number of conjugated and unconjugated bile acids. Expression of the MRP3 gene is increased during pathological states associated with elevated bile acid concentrations indicating a role transporter and bile acid of with bile the of the the and of a acid and the bile acid a of with a and of the of the of of of with of the gene the of associated with and of the a role the the of bile acid of the The multidrug resistance-associated protein of multidrug resistance-associated protein of transporter is of a number of the of a of the of transporter the a number of and a of and a of and and The of with increased of and is of the of multidrug and The multidrug resistance-associated protein 3 is capable of transporting a of and of a number of and The of transporter the of bile and bile acid a role bile acid of bile a of that The bile acid and acid the bile with and and the the bile a of the the bile and the and of and of bile the and the the the of and bile and bile bile the and bile and the concentrations of bile acid of the of of is pathological associated with elevated bile acid concentrations a number of of The of and of is with a role protein the of bile Expression of MRP3 a number of bile the bile the of the of the MRP3 bile the of bile acid increased gene a bile MRP3 a MRP3 bile of a number of the and the the of bile acid and and the of bile acid and bile acid that bile of the the and a of bile acids. The of a of and the and and a and and during with of of of of of a of with of the and and and the and with the of and of and the the the the and of the the of the a a of The the a the a and the and The the of the a the The the and and The and a and Expression the of the the of the with the the the and a and a the and The with and the that with the of the the and and a the The with the The a with and the that with the the and and The and a of of and of the a the of the and of the with of a and the of the The with and the that with the and and the with of of the with of The and and The with the a of of the of and of of number a of the and a the and a and and a of with and a of and with of of of and a of and the with the acid acid acid acid the and a of the and a a Expression and the with the The a a of with The and a of of and the of the the of a The a and the of a the the a of a and a protein the and The a and the The of the the the The the and a a a that The a of and with the with the concentrations and a and gene the and Expression of the of the and of the a and a of the of the the a a the of the and a of the a with the with the with the that of the with the the the of and the of a of the gene the gene the gene of of The gene is and of a protein of The protein and the and of the of with bile the of the and and of the the of the of the of the gene of the The of and bile The of the of of with and of with with with and of with the with and and with of of the the of the of the and with the and and with the with the of the with and a with with with with and of with of the of with and with and that of the the a the of the of the with a the and the the with the and the the of with and with with a a the and the the with the and the of bile the a with the and and The of with the is the of and is the protein transporting bile the the and conjugated and unconjugated bile with and the of with the bile and acid of the the of a bile acid and of the the bile and of the the of and a of the bile acid a of a of of the with the of the of concentrations of the of bile concentrations the and of the bile a bile acid of the the and of the with of the and a of concentrations of and that the and bile a of the bile with a and and the with of bile acids. and with the and and the with bile the and that with the and and the with the and that and of the of the and that and a of with and of and with of and the of and with the of the the of the of the the of the of the of the with a with the and and the with and and of the the of a and of the the of the the of the a of the that the the of a of the of the the of and the with of and the of the of a of a of the of the of the of the a the of the with and and with the and bile of a the the and a with a a and a of the of the with and the with the with the a the the with and and with and that that the of the and the of the and of and the a MRP3 with a of the a the of the gene and a of with and of the and with the the of a the of a with the of the of and the of a of the the of and with the of a of of of the MRP3 a of the with and the the and the and with a number of the of the with the MRP3 of a the the of with with that the of the of the of and the the of a with the the that of the gene with and bile a of the a the of the and and of the of the the is the the of and a the a that of the of the and and the and a MRP3 the concentrations the a MRP3 a and and a a The is the of the of the gene of gene of of and the of the of 3 of of bile and bile acid of with of a of the the increased of and The and a and the of of the the of that that of with a role bile acid and bile of the gene with of of a of the and and of and and and and that the and the role of the gene of the a of the the the of the of a of of the of with of with the the of gene that with a a of the of with the of with of of the of the of of of that the the of with of the of a of and of of gene and with the concentrations of the with The and and and that with with a and the with and the with and MRP3 and with the of the the of and of the increased with with and gene the increased of the a bile acid of the gene is a the bile of the bile and a the of a of the the of the that bile acids. that a and with of of the and bile acids. the of the of and a that of the a with of the of with increased of and of a role the and of the of the and the The the of and of of and the of and and that the the of of the and the the is a of bile acid of of that the bile acid with the the is bile acid of the the of capable of the and of the the of the of is a the of the gene the a gene The of is and is the a role MRP3 is a transporter capable of transporting a of anion bile acid The of is pathological associated with elevated bile acid concentrations a number of of of MRP3 of a bile acid elevated of bile acids. The and of the gene and with the bile of bile acid bile acid the and and is the of bile acid and of bile acid and bile acid a bile and a of and anion transporting gene of the of and MRP3 is bile the of the of bile acid the of of that the of concentrations of bile acids. of MRP3 gene during the of bile The of the a role the the of and the of that the of is the the of the is that of gene bile the of transporter is the of and bile acid concentrations elevated and bile is the bile acid and the number of of the of the of and the the and the of the and bile a and the with is the of the bile acid the bile that the the and is a of of The the the the concentrations of bile of of and of and is a the of bile the of and the the multispecific anion the and with the of the of of the is a the conjugated with and the bile of of and the of bile acid the The of the and the of a of bile acid a and of the gene associated with a the of of bile acid the of the of the bile acid the of of and of and is a the of bile and multispecific anion the and The of of the is a of the of the and a bile the of the the of the of the of the is the during that of the the and of bile the the of the and The multidrug resistance-associated protein of multidrug resistance-associated protein of transporter is of a number of the of a of the of transporter the a number of and a of and a of and and The of with increased of and is of the of multidrug and The multidrug resistance-associated protein 3 is capable of transporting a of and of a number of and The of transporter the of bile and bile acid a role bile acid The of bile a of that The bile acid and acid the bile with and and the the bile a of the the bile and the and of and of bile the and the the the of and bile and bile bile the and bile and the concentrations of bile acid of the of Expression of is pathological associated with elevated bile acid concentrations a number of of The of and of is with a role protein the of bile Expression of MRP3 a number of bile the bile the of the of the MRP3 bile the of bile acid increased gene a bile MRP3 a MRP3 bile of a number of the and the the of bile acid and and the of bile acid and bile acid that bile of the the and a of bile acids. 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concentrations and a and gene the and and a and and during with of of of of of a of with of the and and and the and with the of and of and the the the the and of the the of the a a of The the a the a and the and The the of the a the The the and and The and a and Expression the of the the of the with the the the and a and a the and The with and the that with the of the the and and a the The with the The a with and the that with the the and and The and a of of and of the a the of the and of the with of a and the of the The with and the that with the and and the with of of the with of The and and The with the a of of the of and of of number a of the and a the and a and and a of with and a of and with of of of and a of and the with the acid acid acid acid the and a of the and a a Expression and the with the The a a of with The and a of of and the of the the of a The a and the of a the the a of a and a protein the and The a and the The of the the the The the and a a a that The a of and with the with the concentrations and a and gene the and Expression of the of the and of the a and a of the of the the a a the of the and a of the a with the with the with the that of the with the the the of and the of a of the gene the gene the gene of of The gene is and of a protein of The protein and the and of the of with bile the of the and and of the the of the of the of the gene of the The of and bile The of the of of with and of with with with and of with the with and and with of of the the of the of the and with the and and with the with the of the with and a with with with with and of with of the of with and with and that of the the a the of the the of bile the a with the and and The of with the is the of and is the protein transporting bile the the and conjugated and unconjugated bile with and the of with the bile and acid of the the of a bile acid and of the the bile and of the the of and a of the bile acid a of a of of the with the of the of concentrations of the of bile concentrations the and of the bile a bile acid of the the and of the with of the and a of concentrations of and that the and bile a of the bile with a and and the with of bile acids. and with the and and the with bile the and that with the and and the with the and that and of the of the and that and a of with and of and with of and the of and with the of the the of the of the the of the of the of the with a with the and and the with and and of the the of a and of the the of the the of the a of the that the the of a of the of the the of and the with of and the of the of a of a of the of the of the of the a the of the with and and with the and bile of a the the and a with a a and a of the of the with and the with the with the a the the with and and with and that that the of the and the of the and of and the a MRP3 with a of the a the of the gene and a of with and of the and with the the of a the of a with the of the of and the of a of the the of and with the of a of of of the MRP3 a of the with and the the and the and with a number of the of the with the MRP3 of a the the of with with that the of the of the of and the the of a with the the that of the gene with and bile a of the a the of the and and of the of the the is the the of and a the a that of the of the and and the and a MRP3 the concentrations the a MRP3 a and and a a The is the of the of the gene of gene of of and the of the of 3 of of bile and bile acid of with of a of the the increased of and The and a and the of of the the of that that of with a role bile acid and bile of the gene with of of a of the and and of and and and and that the and the role of the gene of the a of the the the of the of a of of the of with of with the the of gene that with a a of the of with the of with of of the of the of of of that the the of with of the of a of and of of gene and with the concentrations of the with The and and and that with with a and the with and the with and MRP3 and with the of the the of and of the increased with with and gene the increased and Expression of the of the and of the a and a of the of the the a a the of the and a of the a with the with the with the that of the with the the the of and the of a of the gene the gene the gene of of The gene is and of a protein of The protein and the and of the of with bile the of the and and of the the of the of the of the gene of the The of and bile The of the of of with and of with with with and of with the with and and with of of the the of the of the and with the and and with the with the of the with and a with with with with and of with of the of with and with and that of the the a the of the the of bile the a with the and and The of with the is the of and is the protein transporting bile the the and conjugated and unconjugated bile with and the of with the bile and acid of the the of a bile acid and of the the bile and of the the of and a of the bile acid a of a of of the with the of the of concentrations of the of bile concentrations the and of the bile a bile acid of the the and of the with of the and a of concentrations of and that the and bile a and of the of the and that and a of with and of and with of and the of and with the of the the of the of the the of the of the and of the the of a and of the the of the the of the a of the that the the of a of the of the the of and the with of and the of the of a of a of the of the of the of the a the of the with and and with that the of the and the of the and of and the a MRP3 with a of the a the of the gene and a of with and of the and with the the of a the of a with the of the of and the of a of the the of and with the of a of of of the MRP3 a of the with and the the and the and with a number of the of the with the MRP3 of a the the of with with that the of the of the of and the the of a with the the that of the gene with and bile a of the a the of of the of the gene of gene of of and the of the of 3 of of bile and bile acid of with of a of the the increased of and The and a and the of of the the of that that of with a role bile acid and bile and the role of the gene of the a of the the the of the of a of of the of with of with the the of gene that with a a of the of with the of with of of the of the of of of that the the of with of the of a of and of the of the the of and of the increased with with and gene the increased of the a bile acid of the gene is a the bile of the bile and a the of a of the the of the that bile acids. that a and with of of the and bile acids. the of the of and a that of the a with of the of with increased of and of a role the and of the of the and the The the of and of of and the of and and that the the of of the and the the is a of bile acid of of that the bile acid with the the is bile acid of the the of capable of the and of the the of the of is a the of the gene the a gene The of is and is the a role MRP3 is a transporter capable of transporting a of anion bile acid The of is pathological associated with elevated bile acid concentrations a number of of of MRP3 of a bile acid elevated of bile acids. The and of the gene and with the bile of bile acid bile acid the and and is the of bile acid and of bile acid and bile acid a bile and a of and anion transporting gene of the of and MRP3 is bile the of the of bile acid the of of that the of concentrations of bile acids. of MRP3 gene during the of bile The of the a role the the of and the of that the of is the the of the is that of gene bile the of transporter is the of and bile acid concentrations elevated and bile is the bile acid and the number of of the of the of and the the and the of the and bile a and the with is the of the bile acid the bile that the the and is a of of The the the the concentrations of bile of of and of and is a the of bile the of and the the multispecific anion the and with the of the of of the is a the conjugated with and the bile of of and the of bile acid the The of the and the of a of bile acid a and of the gene associated with a the of of bile acid a bile the of the the of the of the of the is the during that of the the and of bile the the of the and The of the a bile acid of the gene is a the bile of the bile and a the of a of the the of the that bile acids. that a and with of of the and bile acids. the of the of and a that of the a with of the of with increased of and of a role the and of the of the and the The the of and of of and the of and and that the the of of the and the the is a of bile acid of of that the bile acid with the the is bile acid of the the of capable of the and of the the of the of is a the of the gene the a gene The of is and is the a role MRP3 is a transporter capable of transporting a of anion bile acid The of is pathological associated with elevated bile acid concentrations a number of of of MRP3 of a bile acid elevated of bile acids. The and of the gene and with the bile of bile acid bile acid the and and is the of bile acid and of bile acid and bile acid a bile and a of and anion transporting gene of the of and MRP3 is bile the of the of bile acid the of of that the of concentrations of bile acids. of MRP3 gene during the of bile The of the a role the the of and the of that the of is the the of the is that of gene bile the of transporter is the of and bile acid concentrations elevated and bile is the bile acid and the number of of the of the of and the the and the of the and bile a and the with is the of the bile acid the bile that the the and is a of of The the the the concentrations of bile of of and of and is a the of bile the of and the the multispecific anion the and with the of the of of the is a the conjugated with and the bile of of and the of bile acid the The of the and the of a of bile acid a and of the gene associated with a the of of bile acid a bile the of the the of the of the of the is the during that of the the and of bile the the of the and

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.

Comment cette classification a été obtenuedéplier

Prédiction distillée sur la base complète

Imitation des enseignants

Ni prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.

score de la tête « metaresearch » (Codex)0,000
score de la tête « metaresearch » (Gemma)0,000
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Expérimental (laboratoire) · Signal consensuel: Expérimental (laboratoire)
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,010
Score d'incertitude au seuil0,486

Scores Codex et Gemma par catégorie

CatégorieCodexGemma
Métarecherche0,0000,000
Méta-épidémiologie (sens strict)0,0000,000
Méta-épidémiologie (sens large)0,0000,000
Bibliométrie0,0000,000
Études des sciences et des technologies0,0000,000
Communication savante0,0000,000
Science ouverte0,0000,000
Intégrité de la recherche0,0000,000
Charge utile insuffisante (le modèle a refusé de juger)0,0000,000

Scores machine (provisoires)

Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.

Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.

Tête enseignante Opus0,012
Tête enseignante GPT0,236
Écart entre enseignants0,224 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle

Classification

machine, non validée

Prédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.

Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeExpérimental (laboratoire)
Domainenon disponible
GenreEmpirique

Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».

En bref

Citations91
Publié2005
Routes d'admission1
Résumé présentoui

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