Integrative analysis of 111 reference human epigenomes
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Résumé
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease. This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease. The goal of the NIH Roadmap Epigenomics Consortium was to generate a reference collection of human epigenomes for primary cells and tissues. This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. The results show that disease and trait-associated genetic variants are enriched in predicted tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits and providing a resource for interpreting the molecular basis of human disease.
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La notice
- Revue
- Nature
- Thématique
- Epigenetics and DNA Methylation
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- Simon Fraser UniversityUniversity of British ColumbiaCanada's Michael Smith Genome Sciences CentreBC Cancer Agency
- Organismes subventionnaires
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCommon FundNational Institute of Environmental Health SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on Deafness and Other Communication DisordersNational Institute on Drug AbuseNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute on AgingTsinghua National Laboratory for Information Science and TechnologyNational Center for Advancing Translational SciencesNational Human Genome Research InstituteTsinghua UniversityNational Natural Science Foundation of ChinaNational Institutes of HealthNational Science FoundationWashington University in St. LouisNational Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesMassachusetts General HospitalHoward Hughes Medical Institute
- Mots-clés
- EpigenomicsDNA methylationComputational biologyBiologyHuman genomeGeneticsEpigenomeChromatinGenomeGeneGene expression
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