The epithelial–mesenchymal transition: new insights in signaling, development, and disease
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Résumé
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. Interest and research in EMT are currently at a high level, as seen by the attendance at the recent EMT meeting in Vancouver, Canada (October 1-3, 2005). The meeting, which was hosted by The EMT International Association, was the second international EMT meeting, the first being held in Port Douglas, Queensland, Australia in October 2003. The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. These themes continued during the recent meeting in Vancouver. Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. This is particularly important because the potential contribution of EMT during neoplasia is the subject of vigorous scientific debate (Tarin, D., E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996-6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991-5995).
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La notice
- Revue
- The Journal of Cell Biology
- Thématique
- Cancer Cells and Metastasis
- Domaine
- Medicine
- Établissements canadiens
- University of British ColumbiaBC Cancer AgencyUniversity of Ottawa
- Organismes subventionnaires
- Medical Research and Materiel CommandNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthNational Cancer InstituteNational Institute on Alcohol Abuse and AlcoholismCanadian Breast Cancer Research Alliance
- Mots-clés
- Epithelial–mesenchymal transitionBiologyCancerMesenchymal stem cellCancer researchMetastasisBioinformaticsCell biologyGenetics
- Résumé présent dans OpenAlex
- oui