Syrian Golden hamster - A model forExamining Metabolic Effects of Volitional Training.
Notice bibliographique
Résumé
1747 The Syrian Golden hamster is commonly used as a model of dietary induced insulin resistance. Fat metabolism in hamsters closely resembles that in humans and this animal is known to exercise voluntarily. PURPOSE: To explore the metabolic effects of volitional training on young, healthy Syrian hamsters. METHODS: Male, 24- day old, hamsters with initial weight of 46.6 ± 0.83g (mean ± SEM), were randomly divided into sedentary (n = 8) and trained (n = 8) groups. The training group had 24-hour access to running wheels over 4 weeks of study. Food consumption, body weight and running distance were recorded daily and blood glucose was measured once per week. Non-fasted animals were euthanized by decapitation under CO2 anaesthesia and blood and tissues were collected for analysis. Plasma leptin, insulin, GLP-1, glucagon and amylin concentrations were measured in 10ul of serum using a Rat/Mouse Endocrine Panel (Linco Research, Inc.). RESULTS: The distance ran increased during the training period from 12.8 ± 1.11km/day at week 1 to 20.3 ± 0.82km/day at week 4. By the second week, food consumption was significantly higher (p<0.01) in trained (9.6 ± 0.2g/day) than in sedentary (6.48 ± 0.13g/day) animals. Although both groups gained weight, there was no difference in body mass between groups at any time point. Right visceral fat pad was larger (p<0.001) in sedentary (0.72 ± 0.04g) than in trained (0.24 ± 0.02g) animals. There was no difference in the blood glucose over the duration of the study between the trained and sedentary controls (4.6 ± 0.08mM/L vs 4.8 ± 0.1mM/L respectively). Leptin levels in sedentary hamsters were higher (p<0.05) than in trained hamsters (92.2 ± 15.7pM vs 35.5 ± 6.17pM, respectively). No significant difference was seen between the trained and sedentary animals in plasma insulin (284 ± 50.6pM vs 291.6 ± 49.7pM) nor GLP-1 (14.57 ± 3.9pM vs 10.93 ± 1.4pM) levels. Plasma glucagon and amylin were not detectible in sufficient animals to allow for comparison between groups. CONCLUSION: Our observations reveal that the extremely high volume of exercise exhibited by the animals, as well as their metabolic profile, may make this animal model particularly useful for the study of physiological effects of heavy endurance type training on metabolism.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,002 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».