Endothelial lipase is associated with inflammation in humans

The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations were measured using a commercial ELISA, and plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations were measured using a commercial assay in a sample of 74 moderately obese men (mean body mass index, 29.8 ± 5.2 kg/m2). Plasma EL concentrations were positively correlated with various indices of obesity, fasting plasma insulin, and plasma CRP, IL-6, and sPLA2-IIA concentrations. Multiple regression analyses revealed that plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations. The combined impact of visceral adipose tissue (VAT) and of an inflammation score on EL concentrations was investigated. Among subjects with high or low a high inflammation score on plasma CRP, IL-6, and sPLA2-IIA concentrations plasma EL concentrations (P = a and plasma EL concentrations among healthy with low or high The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations were measured using a commercial ELISA, and plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations were measured using a commercial assay in a sample of 74 moderately obese men (mean body mass index, 29.8 ± 5.2 kg/m2). Plasma EL concentrations were positively correlated with various indices of obesity, fasting plasma insulin, and plasma CRP, IL-6, and sPLA2-IIA concentrations. Multiple regression analyses revealed that plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations. The combined impact of visceral adipose tissue (VAT) and of an inflammation score on EL concentrations was investigated. Among subjects with high or low a high inflammation score on plasma CRP, IL-6, and sPLA2-IIA concentrations plasma EL concentrations (P = a and plasma EL concentrations among healthy with low or high lipase (EL) is the of the lipase lipase that of a lipase endothelial the lipase which LPL and EL a to the of to a extent of the activity of endothelial that EL is an of concentrations of endothelial that EL was in the of the activity of endothelial a of EL in in of endothelial that EL concentrations in were in and lipase and phospholipase in to a of endothelial that the lipase and phospholipase of endothelial in to were the of the of EL a of EL and protein concentrations were in and in was an EL activity in plasma lipase to the a in that EL to the an with lipase to the a in of EL with the LPL of and on lipase activity in and and lipase activity in in to and lipase concentrations in and with in the of of that plasma EL concentrations in and plasma correlated with body mass index, and with revealed a plasma EL concentrations and visceral that this was the of of EL in visceral adipose tissue was low and endothelial in and EL concentrations in to to investigate the of EL linked to inflammation and to the extent to which the visceral and plasma EL concentrations. the aim of this study was to investigate inflammation is with plasma EL concentrations among healthy sedentary men with various of visceral adipose sample of sedentary men was the in the with and using with and with the the study were the plasma C-reactive protein (CRP) concentrations plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations plasma concentrations and sPLA2-IIA were in this = analyses were in a sample of 74 men. were subjects were in the a the of and body and were measured to The and visceral adipose tissue (VAT) were and endothelial were a were for and Plasma and concentrations were measured to and plasma concentrations in men an or plasma concentrations were with a assay the of Plasma concentrations were measured a commercial which with an for of were in plasma using of various of and to the of concentrations were measured using a commercial to the CRP concentrations were measured with a highly sensitive commercial and of of the for with high plasma C-reactive protein in Plasma concentrations were measured in using a and of in men of the Plasma concentrations were measured with a commercial body LPL and EL mass were measured a LPL and were in plasma with in to a and lipase in and obese and and of and lipase in were of of plasma plasma EL concentrations were measured an using a lipase concentrations in and with The was and the was Plasma concentrations of sPLA2-IIA were measured using a commercial assay to the is an with a for and a with The of for the of sPLA2-IIA was were using were to investigate the plasma EL concentrations and and regression analyses were to of plasma EL concentrations. the model, the of plasma CRP, IL-6, and sPLA2-IIA were investigated. the model, LPL and and plasma concentrations were to the inflammation score to was using of plasma CRP and and of inflammation and to and for the for and and the and and and sPLA2-IIA and and was to in the or was to in the or and were to in the or The inflammation score was low and high of subjects with high or low were using the of the The of the was using the of the of the on and of in in plasma EL concentrations the were among were using the < was for in this study = were and of and were a with a body mass of 29.8 ± 5.2 a plasma a with plasma and concentrations of ± ± and ± Plasma EL concentrations were and to of men = ± ± mass ± = ± adipose tissue ± ± ± ± ± ± ± concentrations in plasma ± ± endothelial = EL concentrations in plasma ± in a Plasma EL concentrations were positively correlated with fasting plasma insulin, CRP, IL-6, and concentrations and were correlated with plasma LPL activity among this sample of men for were were for in plasma EL concentrations were with Plasma with plasma EL concentrations = = and was in the inflammation with plasma EL concentrations = = adipose tissue activity = activity = C-reactive IL-6, secretory phospholipase A2 type for = = in a Multiple regression analyses were to the of various inflammation to the variance in EL concentrations. The to in plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in plasma EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations Plasma concentrations to the variance in plasma EL concentrations in this the model, the inflammation score explained (P < 0.0001) of the variance in plasma EL LPL activity to (P = of this were of and regression analyses the of inflammation to plasma EL adipose adipose tissue CRP, IL-6, and sPLA2-IIA concentrations and LPL and were in a with and the were into on the CRP of that among men with the plasma CRP concentrations the plasma EL and concentrations were of men the and with low plasma CRP concentrations. the with high plasma CRP concentrations and men with the with low plasma CRP concentrations plasma EL concentrations. plasma EL concentrations to the inflammation score among subjects with and the that among men with high inflammation plasma EL concentrations were in the and of the of inflammation on plasma EL concentrations among men with and the The was or of the the were The CRP of was to subjects with low or high plasma CRP concentrations. The inflammation score on CRP, IL-6, and sPLA2-IIA in and Plasma EL concentrations ± The to the for the on plasma EL for The was using the with the the that was with plasma EL concentrations among lipase concentrations in and with and endothelial that the in plasma EL concentrations in to the of a The combined impact of and the inflammation score on EL concentrations was on the of the of the of or that subjects with a high inflammation of the plasma EL impact of inflammation and visceral adipose tissue (VAT) on plasma EL concentrations. The was to subjects with low or high and for a of the inflammation score on CRP, IL-6, and sPLA2-IIA concentrations. Plasma EL concentrations ± The to the for the on plasma EL with the the in sedentary men that is a plasma concentrations of CRP and and plasma EL concentrations. analyses revealed that plasma LPL activity and plasma CRP concentrations were the of plasma EL concentrations an inflammation score on plasma CRP, IL-6, and sPLA2-IIA concentrations was the of plasma EL concentrations. with the and the with a high inflammation score plasma EL concentrations with men the and with a low plasma EL concentrations and CRP and among in which to EL concentrations in endothelial of endothelial lipase and phospholipase in to a of endothelial and in a of inflammation lipase to the a in The LPL activity and EL was that explained with plasma concentrations. Plasma EL concentrations were positively correlated with which is to a of LPL the EL and concentrations for concentrations to investigate this is a of plasma concentrations of CRP and C-reactive protein in healthy with obesity, and endothelial for adipose with plasma concentrations of CRP C-reactive of the of is that the is an in the of the in a of and adipose of obese subjects and and adipose tissue of in and that that was with plasma EL concentrations in lipase concentrations in and with and endothelial study to that the in plasma EL concentrations in to the of a study for the that with EL of the of of the with that CRP concentrations the of the study of C-reactive protein in to the of and in the an plasma EL concentrations and a of to the high plasma concentrations among men lipase concentrations in and with study that among men with the plasma CRP concentrations high plasma EL concentrations that were of men the and with low CRP concentrations. were plasma concentrations were this the impact of the score on plasma EL concentrations in to the revealed that men with the plasma EL concentrations healthy of inflammation that the with the EL is in that that with plasma EL concentrations among healthy men in an of EL the of plasma EL is with lipase to the a in that EL a in the of that EL on the endothelial to the an with LPL to to endothelial lipase a lipase to endothelial that EL in endothelial of inflammation a of to to LPL and of and on lipase activity in and lipase of EL a to for in a of EL in the of EL in and the of of endothelial lipase in EL and activity of endothelial lipase and phospholipase in to a of endothelial and EL to the lipase to the a in for the CRP and concentrations and plasma EL concentrations among healthy and with the with low or high which EL and to in plasma concentrations to in the the of in to plasma EL concentrations and inflammation lipase (EL) is the of the lipase lipase that of a lipase endothelial the lipase which LPL and EL a to the of to a extent of the activity of endothelial that EL is an of concentrations of endothelial that EL was in the of the activity of endothelial a of EL in in of endothelial that EL concentrations in were in and lipase and phospholipase in to a of endothelial that the lipase and phospholipase of endothelial in to were the of the of EL a of EL and protein concentrations were in and in was an EL activity in plasma lipase to the a in that EL to the an with lipase to the a in of EL with the LPL of and on lipase activity in and and lipase activity in in to and lipase concentrations in and with in the of of that plasma EL concentrations in and plasma correlated with body mass index, and with revealed a plasma EL concentrations and visceral that this was the of of EL in visceral adipose tissue was low and endothelial in and EL concentrations in to to investigate the of EL linked to inflammation and to the extent to which the visceral and plasma EL concentrations. the aim of this study was to investigate inflammation is with plasma EL concentrations among healthy sedentary men with various of visceral adipose sample of sedentary men was the in the with and using with and with the the study were the plasma C-reactive protein (CRP) concentrations plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations plasma concentrations and sPLA2-IIA were in this = analyses were in a sample of 74 men. were subjects were in the a the of and body and were measured to The and visceral adipose tissue (VAT) were and endothelial were a were for and Plasma and concentrations were measured to and plasma concentrations in men an or plasma concentrations were with a assay the of Plasma concentrations were measured a commercial which with an for of were in plasma using of various of and to the of concentrations were measured using a commercial to the CRP concentrations were measured with a highly sensitive commercial and of of the for with high plasma C-reactive protein in Plasma concentrations were measured in using a and of in men of the Plasma concentrations were measured with a commercial body LPL and EL mass were measured a LPL and were in plasma with in to a and lipase in and obese and and of and lipase in were of of plasma plasma EL concentrations were measured an using a lipase concentrations in and with The was and the was Plasma concentrations of sPLA2-IIA were measured using a commercial assay to the is an with a for and a with The of for the of sPLA2-IIA was were using were to investigate the plasma EL concentrations and and regression analyses were to of plasma EL concentrations. the model, the of plasma CRP, IL-6, and sPLA2-IIA were investigated. the model, LPL and and plasma concentrations were to the inflammation score to was using of plasma CRP and and of inflammation and to and for the for and and the and and and sPLA2-IIA and and was to in the or was to in the or and were to in the or The inflammation score was low and high of subjects with high or low were using the of the The of the was using the of the of the on and of in in plasma EL concentrations the were among were using the < was for sample of sedentary men was the in the with and using with and with the the study were the plasma C-reactive protein (CRP) concentrations plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations plasma concentrations and sPLA2-IIA were in this = analyses were in a sample of 74 men. were subjects were in the a the of sample of sedentary men was the in the with and using with and with the the study were the plasma C-reactive protein (CRP) concentrations plasma secretory phospholipase A2 type IIA (sPLA2-IIA) concentrations plasma concentrations and sPLA2-IIA were in this = analyses were in a sample of 74 men. were subjects were in the a the of and body and were measured to The and visceral adipose tissue (VAT) were and endothelial and were measured to The and visceral adipose tissue (VAT) were and endothelial were a were for and Plasma and concentrations were measured to and plasma concentrations in men an or plasma concentrations were with a assay the of Plasma concentrations were measured a commercial which with an for of were in plasma using of various of and to the of concentrations were measured using a commercial to the CRP concentrations were measured with a highly sensitive commercial and of of the for with high plasma C-reactive protein in Plasma concentrations were measured in using a and of in men of the Plasma concentrations were measured with a commercial body LPL and EL mass were measured a LPL and were in plasma with in to a and lipase in and obese and and of and lipase in were of of plasma plasma EL concentrations were measured an using a lipase concentrations in and with The was and the was Plasma concentrations of sPLA2-IIA were measured using a commercial assay to the is an with a for and a with The of for the of sPLA2-IIA was were a were for and Plasma and concentrations were measured to and plasma concentrations in men an or plasma concentrations were with a assay the of Plasma concentrations were measured a commercial which with an for of were in plasma using of various of and to the of concentrations were measured using a commercial to the CRP concentrations were measured with a highly sensitive commercial and of of the for with high plasma C-reactive protein in Plasma concentrations were measured in using a and of in men of the Plasma concentrations were measured with a commercial Plasma body LPL and EL mass were measured a LPL and were in plasma with in to a and lipase in and obese and and of and lipase in were of of plasma plasma EL concentrations were measured an using a lipase concentrations in and with The was and the was Plasma concentrations of sPLA2-IIA were measured using a commercial assay to the is an with a for and a with The of for the of sPLA2-IIA was were using were to investigate the plasma EL concentrations and and regression analyses were to of plasma EL concentrations. the model, the of plasma CRP, IL-6, and sPLA2-IIA were investigated. the model, LPL and and plasma concentrations were to the inflammation score to was using of plasma CRP and and of inflammation and to and for the for and and the and and and sPLA2-IIA and and was to in the or was to in the or and were to in the or The inflammation score was low and high of subjects with high or low were using the of the The of the was using the of the of the on and of in in plasma EL concentrations the were among were using the < was for were using were to investigate the plasma EL concentrations and and regression analyses were to of plasma EL concentrations. the model, the of plasma CRP, IL-6, and sPLA2-IIA were investigated. the model, LPL and and plasma concentrations were to the inflammation score to was using of plasma CRP and and of inflammation and to and for the for and and the and and and sPLA2-IIA and and was to in the or was to in the or and were to in the or The inflammation score was low and high of subjects with high or low were using the of the The of the was using the of the of the on and of in in plasma EL concentrations the were among were using the < was for in this study = were and of and were a with a body mass of 29.8 ± 5.2 a plasma a with plasma and concentrations of ± ± and ± Plasma EL concentrations were and to of men = ± ± mass ± = ± adipose tissue ± ± ± ± ± ± ± concentrations in plasma ± ± endothelial = EL concentrations in plasma ± in a Plasma EL concentrations were positively correlated with fasting plasma insulin, CRP, IL-6, and concentrations and were correlated with plasma LPL activity among this sample of men for were were for in plasma EL concentrations were with Plasma with plasma EL concentrations = = and was in the inflammation with plasma EL concentrations = = adipose tissue activity = activity = C-reactive IL-6, secretory phospholipase A2 type for = = in a Multiple regression analyses were to the of various inflammation to the variance in EL concentrations. The to in plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in plasma EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations Plasma concentrations to the variance in plasma EL concentrations in this the model, the inflammation score explained (P < 0.0001) of the variance in plasma EL LPL activity to (P = of this were of and regression analyses the of inflammation to plasma EL adipose adipose tissue CRP, IL-6, and sPLA2-IIA concentrations and LPL and were in a with and the were into on the CRP of that among men with the plasma CRP concentrations the plasma EL and concentrations were of men the and with low plasma CRP concentrations. the with high plasma CRP concentrations and men with the with low plasma CRP concentrations plasma EL concentrations. plasma EL concentrations to the inflammation score among subjects with and the that among men with high inflammation plasma EL concentrations were in the and of the that was with plasma EL concentrations among lipase concentrations in and with and endothelial that the in plasma EL concentrations in to the of a The combined impact of and the inflammation score on EL concentrations was on the of the of the of or that subjects with a high inflammation of the plasma EL impact of inflammation and visceral adipose tissue (VAT) on plasma EL concentrations. The was to subjects with low or high and for a of the inflammation score on CRP, IL-6, and sPLA2-IIA concentrations. Plasma EL concentrations ± The to the for the on plasma EL with the the in this study = were and of and were a with a body mass of 29.8 ± 5.2 a plasma a with plasma and concentrations of ± ± and ± Plasma EL concentrations were and to endothelial Plasma EL concentrations were positively correlated with fasting plasma insulin, CRP, IL-6, and concentrations and were correlated with plasma LPL activity among this sample of men for were were for in plasma EL concentrations were with Plasma with plasma EL concentrations = = and was in the inflammation CRP, C-reactive IL-6, secretory phospholipase A2 type for Multiple regression analyses were to the of various inflammation to the variance in EL concentrations. The to in plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in plasma EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations Plasma concentrations to the variance in plasma EL concentrations in this the model, the inflammation score explained (P < 0.0001) of the variance in plasma EL LPL activity to (P = of this were of and concentrations. Plasma CRP, IL-6, and sPLA2-IIA concentrations and LPL and were with and the were into on the CRP of that among men with the plasma CRP concentrations the plasma EL and concentrations were of men the and with low plasma CRP concentrations. the with high plasma CRP concentrations and men with the with low plasma CRP concentrations plasma EL concentrations. plasma EL concentrations to the inflammation score among subjects with and the that among men with high inflammation plasma EL concentrations were in the and of the that was with plasma EL concentrations among lipase concentrations in and with and endothelial that the in plasma EL concentrations in to the of a The combined impact of and the inflammation score on EL concentrations was on the of the of the of or that subjects with a high inflammation of the plasma EL concentrations. in sedentary men that is a plasma concentrations of CRP and and plasma EL concentrations. analyses revealed that plasma LPL activity and plasma CRP concentrations were the of plasma EL concentrations an inflammation score on plasma CRP, IL-6, and sPLA2-IIA concentrations was the of plasma EL concentrations. with the and the with a high inflammation score plasma EL concentrations with men the and with a low plasma EL concentrations and CRP and among in which to EL concentrations in endothelial of endothelial lipase and phospholipase in to a of endothelial and in a of inflammation lipase to the a in The LPL activity and EL was that explained with plasma concentrations. Plasma EL concentrations were positively correlated with which is to a of LPL the EL and concentrations for concentrations to investigate this is a of plasma concentrations of CRP and C-reactive protein in healthy with obesity, and endothelial for adipose with plasma concentrations of CRP C-reactive of the of is that the is an in the of the in a of and adipose of obese subjects and and adipose tissue of in and that that was with plasma EL concentrations in lipase concentrations in and with and endothelial study to that the in plasma EL concentrations in to the of a study for the that with EL of the of of the with that CRP concentrations the of the study of C-reactive protein in to the of and in the an plasma EL concentrations and a of to the high plasma concentrations among men lipase concentrations in and with study that among men with the plasma CRP concentrations high plasma EL concentrations that were of men the and with low CRP concentrations. were plasma concentrations were this the impact of the score on plasma EL concentrations in to the revealed that men with the plasma EL concentrations healthy of inflammation that the with the EL is in that that with plasma EL concentrations among healthy men in an of EL the of plasma EL is with lipase to the a in that EL a in the of that EL on the endothelial to the an with LPL to to endothelial lipase a lipase to endothelial that EL in endothelial of inflammation a of to to LPL and of and on lipase activity in and lipase of EL a to for in a of EL in the of EL in and the of of endothelial lipase in EL and activity of endothelial lipase and phospholipase in to a of endothelial and EL to the lipase to the a in for the CRP and concentrations and plasma EL concentrations among healthy and with the with low or high which EL and to in plasma concentrations to in the the of in to plasma EL concentrations and inflammation in sedentary men that is a plasma concentrations of CRP and and plasma EL concentrations. analyses revealed that plasma LPL activity and plasma CRP concentrations were the of plasma EL concentrations an inflammation score on plasma CRP, IL-6, and sPLA2-IIA concentrations was the of plasma EL concentrations. with the and the with a high inflammation score plasma EL concentrations with men the and with a low The plasma EL concentrations and CRP and among in which to EL concentrations in endothelial of endothelial lipase and phospholipase in to a of endothelial and in a of inflammation lipase to the a in The LPL activity and EL was that explained with plasma concentrations. Plasma EL concentrations were positively correlated with which is to a of LPL the EL and concentrations for concentrations to investigate this is a of plasma concentrations of CRP and C-reactive protein in healthy with obesity, and endothelial for adipose with plasma concentrations of CRP C-reactive of the of is that the is an in the of the in a of and adipose of obese subjects and and adipose tissue of in and that that was with plasma EL concentrations in lipase concentrations in and with and endothelial study to that the in plasma EL concentrations in to the of a study for the that with EL of the of of the with that CRP concentrations the of the study of C-reactive protein in to the of and in the an plasma EL concentrations and a of to the high plasma concentrations among men lipase concentrations in and with study that among men with the plasma CRP concentrations high plasma EL concentrations that were of men the and with low CRP concentrations. were plasma concentrations were this the impact of the score on plasma EL concentrations in to the revealed that men with the plasma EL concentrations healthy of inflammation that the with the EL is in that The that with plasma EL concentrations among healthy men in an of EL the of plasma EL is with lipase to the a in that EL a in the of that EL on the endothelial to the an with LPL to to endothelial lipase a lipase to endothelial that EL in endothelial of inflammation a of to to LPL and of and on lipase activity in and lipase of EL a to for in a of EL in the of EL in and the of of endothelial lipase in EL and activity of endothelial lipase and phospholipase in to a of endothelial and EL to the lipase to the a in for the CRP and concentrations and plasma EL concentrations among healthy and with the with low or high which EL and to in plasma concentrations to in the the of in to plasma EL concentrations and inflammation is in and the is a the was the of a the of the and the was the of a the was an the of was of was the and

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.