1410 RADICAL CYSTECTOMY FOR CLINICALLY MUSCLE INVASIVE BLADDER CANCER: DOES PRIOR NON-INVASIVE DISEASE AFFECT CLINICAL OUTCOMES?
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Résumé
You have accessJournal of UrologyBladder Cancer: Invasive I1 Apr 20121410 RADICAL CYSTECTOMY FOR CLINICALLY MUSCLE INVASIVE BLADDER CANCER: DOES PRIOR NON-INVASIVE DISEASE AFFECT CLINICAL OUTCOMES? Ahmed Kotb, Evan Kovac, Wassim Kassouf, Joe Chin, Yves Fradet, Jonathan Izawa, Eric Estey, Adrian Fairey, Ricardo Rendon, Ilias Cagiannos, Louis Lacombe, Jean-Baptiste Lattouf, David Bell, Darrel Drachenberg, and Armen Aprikian Ahmed KotbAhmed Kotb Montreal, Canada More articles by this author , Evan KovacEvan Kovac Montreal, Canada More articles by this author , Wassim KassoufWassim Kassouf Montreal, Canada More articles by this author , Joe ChinJoe Chin London, Canada More articles by this author , Yves FradetYves Fradet Quebec City, Canada More articles by this author , Jonathan IzawaJonathan Izawa London, Canada More articles by this author , Eric EsteyEric Estey Edmonton, Canada More articles by this author , Adrian FaireyAdrian Fairey Edmonton, Canada More articles by this author , Ricardo RendonRicardo Rendon Halifax, Canada More articles by this author , Ilias CagiannosIlias Cagiannos Ottawa, Canada More articles by this author , Louis LacombeLouis Lacombe Quebec City, Canada More articles by this author , Jean-Baptiste LattoufJean-Baptiste Lattouf Montreal, Canada More articles by this author , David BellDavid Bell Halifax, Canada More articles by this author , Darrel DrachenbergDarrel Drachenberg Winnipeg, Canada More articles by this author , and Armen AprikianArmen Aprikian Montreal, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1861AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To compare clinical and pathologic outcomes of radical cystectomy for muscle invasive bladder cancer in relation to prior history of non-invasive urothelial carcinoma. METHODS The Canadian Bladder Cancer Network was used to retrospectively analyze data from 1150 patients managed by radical cystectomy for urothelial carcinoma of the bladder. Patients with clinical stage T2 or more were included and divided into two groups: (Group 1) patients with prior history of non-invasive urothelial carcinoma (N=365), and (Group 2) patients with clinical muscle invasive cancer de novo (N=785). Variables analyzed included patient age, gender, pathologic stage, adjuvant chemotherapy, recurrence and mortality. RESULTS Both groups were nearly equal in mean age and gender distribution, with mean ages of 67.2 and 66.7 years, and 79.7% and 79.5%, respectively (P 0.4 and 0.9, respectively). The presence of preoperative hydronephrosis was 20.8% and 32.6% (P 0.0007) for groups 1 and 2, respectively. The rate of higher pathological stage (T3 or T4) was 36.3% and 58% (P <0.0001), positive lymph nodes was 20.1% and 28.8% (P 0.002) and lymphovascular invasion was 31.7% and 46.2% (P 0.0001) for groups 1 and 2, respectively. The rate of adjuvant chemotherapy was 15.5% and 23.3% (P 0.002) for groups 1 and 2, respectively. None of the sampled patients received neoadjuvant chemotherapy. The overall survival (OS) and disease-specific survival (DSS) rates at 5 years was 62% and 70% for group 1 and 51% and 60% for group 2, respectively, while at 10 years, OS and DSS was 46% and 66% for group 1 and 35% and 49% for group 2, respectively (P 0.0001 and 0.0002 respectively). Using multivariate analysis examining factors affecting recurrence and survival, we found that previous non-invasive bladder tumour history was associated with a significantly reduced risk of mortality and recurrence (Hazard ratio of 0.7 for all risks, P 0.0002). CONCLUSIONS Our retrospective study suggests that patients with non-invasive urothelial carcinoma of the bladder that progress to muscle-invasion and require radical cystectomy appear to have better pathologic and clinical outcome than patients presenting with clinical muscle invasive disease de novo. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e573 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ahmed Kotb Montreal, Canada More articles by this author Evan Kovac Montreal, Canada More articles by this author Wassim Kassouf Montreal, Canada More articles by this author Joe Chin London, Canada More articles by this author Yves Fradet Quebec City, Canada More articles by this author Jonathan Izawa London, Canada More articles by this author Eric Estey Edmonton, Canada More articles by this author Adrian Fairey Edmonton, Canada More articles by this author Ricardo Rendon Halifax, Canada More articles by this author Ilias Cagiannos Ottawa, Canada More articles by this author Louis Lacombe Quebec City, Canada More articles by this author Jean-Baptiste Lattouf Montreal, Canada More articles by this author David Bell Halifax, Canada More articles by this author Darrel Drachenberg Winnipeg, Canada More articles by this author Armen Aprikian Montreal, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,011 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,028 | 0,005 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».