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Enregistrement W2082371998 · doi:10.1016/j.ajpath.2010.12.037

Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis

2011· article· en· W2082371998 sur OpenAlexaff
Christian M. Becker, Paul Beaudry, Tae Funakoshi, Ofra Benny, A. Zaslavsky, David Zurakowski, Judah Folkman, Robert J. D’Amato, Sandra Ryeom

Notice bibliographique

RevueAmerican Journal Of Pathology · 2011
Typearticle
Langueen
DomaineMedicine
ThématiqueEndometriosis Research and Treatment
Établissements canadiensAlberta Children's Hospital
Organismes subventionnairesNational Cancer InstituteFondation pour la Recherche MédicaleMedical Research CouncilNational Institute for Health and Care ResearchMax Kade FoundationGarrett B. Smith Foundation
Mots-clésProgenitor cellEndometriosisProgenitorCell biologyEndothelial progenitor cellBiologyStem cellMedicineInternal medicine

Résumé

récupéré en direct d'OpenAlex

Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. Recent data from a variety of angiogenesis-dependent diseases suggest a critical role of bone marrow–derived endothelial progenitor cells (EPCs) in neovascularization. In this study the of and endothelial cells in a of of in the of that a the of endometriotic and of In a bone endothelial cells endometriotic by and of the angiogenesis an of data an role bone marrow–derived endothelial cells in the of and the of a this Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that angiogenesis plays an integral part in the establishment and growth of endometriotic lesions. Recent data from a variety of angiogenesis-dependent diseases suggest a critical role of bone marrow–derived endothelial progenitor cells (EPCs) in neovascularization. In this study the of and endothelial cells in a of of in the of that a the of endometriotic and of In a bone endothelial cells endometriotic by and of the angiogenesis an of data an role bone marrow–derived endothelial cells in the of and the of a this of of disease debilitating and of and In is is of the of the endometriotic the and of a a and of of in of in and and of a of of the of of of endometriotic of the In the is the and is and of an the and In an of and a of Endometriosis and the the of the the of by and that the of a is the establishment and growth of endometriotic and in in of angiogenesis a of and in the growth of endometriotic of in a of of endothelial growth growth and growth of angiogenesis and in endometriotic a of of endothelial of in disease and of in and of endothelial cells endothelial cells from the bone of progenitor endothelial cells endothelial endothelial growth is in endometriotic and of endothelial growth in endothelial growth in of of endothelial growth in the angiogenesis the and in the of is a the of bone marrow–derived endothelial progenitor cells by bone endothelial progenitor in by of and and in by of endothelial growth in of the of of in and the of of the progenitor cells the in progenitor cells of and of endothelial and cells angiogenesis and endothelial and of and the of endothelial cells from of endothelial growth endothelial and endothelial a of that and disease and of in of the of and growth angiogenesis of in the of an of growth and in this study the role of of an of of and a bone the of the of endometriotic lesions. the of and and in the and in and and by the and of from from and from a from of cells of and bone in of and a of from of the of the by the growth of endometriotic the the in and Endometriosis the growth of endometriotic endothelial in and in a of in a the of in the the a and in a in of a and the the the endometrial the a a in the that of endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from progenitor cells In bone from and and bone bone the of the in bone by of and in the of of the of of by and of and of endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor cells the the of cells in and endometriotic from that a bone and in the in and in and and in and the the a and data and and in endothelial angiogenesis by a and of endothelial growth endothelial and endothelial a of endothelial cells in and and bone marrow–derived progenitor endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor endothelial in and and an in and in and and the and from in in and in that a and progenitor cells of and in of cells of and and the and data and data in of of the of of in a of the of in a of by in endometriotic lesions. of endothelial growth endothelial and endothelial a of by of endothelial and and the of and by and in a of and of of endothelial growth endothelial and endothelial a of progenitor cells In the of and a the the the and of the of of angiogenesis in of the of angiogenesis in a in the that a and the of the of endometriotic disease a in a in the and a from the in of and in the and of endothelial cells from endometriotic and endometriotic a the of an the growth of endometriotic endothelial in and in a and growth of in a of of the of in a and and and and and in that that a in the by the of bone cells in the in the endometriotic and in the and endometriotic and and endothelial cells by the of and and of a a in the of endothelial cells the endometriotic in cells in endometriotic lesions. bone from endometriotic from and from and and and of and endothelial cells of cells of cells of cells of and endothelial of endometriotic in bone and of and cells of bone marrow–derived cells in endometriotic in bone marrow–derived cells endothelial cells that and of cells in the endometriotic the the of a in the of endothelial cells in endometriotic and in of cells the of endometriotic by an an endothelial that the of endothelial progenitor cells endometriotic the of and endometriotic growth in and growth of in a of of the of is an of of the angiogenesis and of endometriotic by the the of of and of in the and of and of the of an of the angiogenesis the of the of and of and a the of an of of of of the in the the that the of endothelial cells and endothelial progenitor cells in the of an angiogenesis-dependent the of a in the the study that endothelial progenitor cells in an of and that cells the of the endometriotic lesions. growth of the of the angiogenesis in a of this of and of a role in the angiogenesis-dependent growth of endometriotic and the of a of disease and of is in that growth disease establishment and the angiogenesis in of endothelial and and of in disease and and of angiogenesis in In the the of bone marrow–derived endothelial progenitor cells the of and the in a that the of the the role of in the and of of endothelial and cells angiogenesis and endothelial in and In that of endothelial cells in the bone marrow–derived of bone marrow–derived cells in the this the of bone marrow–derived endothelial cells a of in the in the of endothelial progenitor and the endothelial progenitor cells and in this in in a that cells of endometriotic in a endothelial cells the the and the that the of the endothelial cells in the data suggest that bone marrow–derived endothelial cells this of is a disease that of in the growth and in endometriotic of of endothelial growth in the angiogenesis the and in the of of growth in from in of is a endothelial cells and of It that plays a role in the of bone progenitor cells by bone endothelial progenitor that is of the the of in this data that in the the and in and by a the by a the In a in of and in the and growth of in a of of in the of and of the of of endometriotic in a in in the that a is in growth and growth by cells from of and progenitor cells from the bone of endothelial progenitor in the of and of in ectopic and of and of and of growth in the of endothelial cells in that a and in this in the that of the and in the of cells from the in that this in the this the in a that of the endothelial cells from the a role a in and in and the by angiogenesis a the of angiogenesis in and of angiogenesis in is an of of the by the angiogenesis and in and that the angiogenesis and the and of endometriotic growth the growth of endometriotic endothelial in and in a a is a angiogenesis that endometriotic of that angiogenesis and the of in the that in and study of and of an angiogenesis in in is an of the growth and angiogenesis in and endothelial cells the by and of and endothelial by in and the by the is by and 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the of by and that the of a is the establishment and growth of endometriotic and in in of angiogenesis a of and in the growth of endometriotic of in a of of endothelial growth growth and growth of angiogenesis and in endometriotic a of of endothelial of in disease and of in and of endothelial cells endothelial cells from the bone of progenitor endothelial cells endothelial endothelial growth is in endometriotic and of endothelial growth in endothelial growth in of of endothelial growth in the angiogenesis the and in the of is a the of bone marrow–derived endothelial progenitor cells by bone endothelial progenitor in by of and and in by of endothelial growth in of the of of in and the of of the progenitor cells the in progenitor cells of and of endothelial and cells angiogenesis and endothelial and of and the of endothelial cells from of endothelial growth endothelial and endothelial a of that and disease and of in of the of Endometriosis and growth angiogenesis of in the of an of growth and in this study the role of of an of of and a bone the of the of endometriotic lesions. the of and and in the and in and and by the and of from from and from a from of cells of and bone in of and a of from of the of the by the growth of endometriotic the the in and Endometriosis the growth of endometriotic endothelial in and in a of in a the of in the the a and in a in of a and the the the endometrial the a a in the that of endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from progenitor cells In bone from and and bone bone the of the in bone by of and in the of of the of of by and of and of endothelial cells of endothelial growth endothelial and endothelial a of and the and of endothelial progenitor the endothelial growth of endothelial progenitor cells the the of cells in and 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endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a from of the of the by the growth of endometriotic the the in and Endometriosis the growth of endometriotic endothelial in and in a of in a the of in the the a and in a in of a and the the the endometrial the a a in the that of endometrial tissue. in the of the and the the of the of a the of a the growth of endometriotic and growth of in a of of the of the a In of the in a and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from and of the an of the angiogenesis by and in and the of the the of In the bone bone endometriotic from progenitor cells In bone from and and bone bone the of the in bone by progenitor cells In bone from and and bone bone the of the in bone by of and in the of of the of of by and of and of endothelial cells of endothelial growth endothelial and endothelial a of and the and 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of growth in the of endothelial cells in that a and in this in the that of the and in the of cells from the in that this in the this the in a that of the endothelial cells from the a role a in and in and the by angiogenesis a the of angiogenesis in and of angiogenesis in is an of of the by the angiogenesis and in and that the angiogenesis and the and of endometriotic growth the growth of endometriotic endothelial in and in a a is a angiogenesis that endometriotic of that angiogenesis and the of in the that in and study of and of an angiogenesis in in is an of the growth and angiogenesis in and endothelial cells the by and of and endothelial by in and the by the is by and study that the of in the of that growth of endometriotic lesions. a an of that endometriotic growth and of the of endothelial and of endothelial growth by the angiogenesis of by and endothelial and growth and endothelial growth In data suggest that by cells is by the of the of from the is a role in bone is that in the endometriotic in a progenitor that is in endometriotic and growth of in a of the this the in the In angiogenesis in a and in the of the is that the of the is that bone marrow–derived endothelial cells in a of the of angiogenesis in the establishment and growth of endometriotic and the that endothelial progenitor cells in the of the is the a and in the disease and the of endothelial progenitor and endothelial cells in and and In the study that endothelial progenitor cells in an of and that cells the of the endometriotic lesions. growth of the of the angiogenesis in a of this of and of a role in the angiogenesis-dependent growth of endometriotic and the of a of disease and of Endometriosis is in that growth disease establishment and the angiogenesis in of endothelial and and of in disease and and of angiogenesis in In the the of bone marrow–derived endothelial progenitor cells the of and the in a that the of the lesions. the role of in the and of of endothelial and cells angiogenesis and endothelial in and In that of endothelial cells in the bone marrow–derived of bone marrow–derived cells in the this the of bone marrow–derived endothelial cells a of in the in the of endothelial progenitor and the endothelial progenitor cells and in this in in a that cells of endometriotic in a endothelial cells the the and the that the of the endothelial cells in the data suggest that bone marrow–derived endothelial cells this of Endometriosis is a disease that of in the growth and in endometriotic of of endothelial growth in the angiogenesis the and in the of of growth in from in of is a endothelial cells and of It that plays a role in the of bone progenitor cells by bone endothelial progenitor that is of the the of in this data that in the the and in and by a the by a the In a in of and in the and growth of in a of of in the of and of the of of endometriotic in a in in the that a is in growth and growth by cells from of and progenitor cells from the bone of endothelial progenitor in the of and of in ectopic and of and of and of growth in the of endothelial cells in that a and in this in the that of the and in the of cells from the in that this in the this the in a that of the endothelial cells from the a role a in and in and the by angiogenesis a the of angiogenesis in and of angiogenesis in is an of of the by the angiogenesis and in and that the angiogenesis and the and of endometriotic growth the growth of endometriotic endothelial in and in a a is a angiogenesis that endometriotic of that angiogenesis and the of in the that in and study of and of an angiogenesis in in is an of the growth and angiogenesis in and endothelial cells the by and of and endothelial by in and the by the is by and In study that the of in the of that growth of endometriotic lesions. a an of that endometriotic growth and of the of endothelial and of endothelial growth by the angiogenesis of by and endothelial and growth and endothelial growth In data suggest that by cells is by the of the of from the is a role in bone is that in the endometriotic in a progenitor that is in endometriotic and growth of in a of the this the in the In angiogenesis in a and in the of the is that the of the is In that bone marrow–derived endothelial cells in a of the of angiogenesis in the establishment and growth of endometriotic and the that endothelial progenitor cells in the of the is the a and in the disease and the of endothelial progenitor and endothelial cells in and and and the of the and and data and of and and from and the endothelial cells characterized and progenitor and and of and and from and the endothelial cells characterized and progenitor and in of a of cells that the from and and of and and

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.

Comment cette classification a été obtenuedéplier

Prédiction distillée sur la base complète

Imitation des enseignants

Ni prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.

score de la tête « metaresearch » (Codex)0,000
score de la tête « metaresearch » (Gemma)0,002
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Expérimental (laboratoire) · Signal consensuel: Expérimental (laboratoire)
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,097
Score d'incertitude au seuil0,465

Scores Codex et Gemma par catégorie

CatégorieCodexGemma
Métarecherche0,0000,002
Méta-épidémiologie (sens strict)0,0000,000
Méta-épidémiologie (sens large)0,0010,000
Bibliométrie0,0010,001
Études des sciences et des technologies0,0000,000
Communication savante0,0000,000
Science ouverte0,0000,000
Intégrité de la recherche0,0000,000
Charge utile insuffisante (le modèle a refusé de juger)0,0000,000

Scores machine (provisoires)

Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.

Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.

Tête enseignante Opus0,046
Tête enseignante GPT0,299
Écart entre enseignants0,253 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle

Classification

machine, non validée

Prédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.

Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeExpérimental (laboratoire)
Domainenon disponible
GenreEmpirique

Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».

En bref

Citations81
Publié2011
Routes d'admission1
Résumé présentoui

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