The Effect of Bone Regeneration According to Maintenance Period of the PTFE Membrane in Rabbit Calvarial Defects
Notice bibliographique
Résumé
The purpose of this study is to figure out the effect of maintaining period of PTFE membrane used in GBR with autogeonous bone, heterogeneous bone and synthetic bone on bone formation on rabbits' cranial defect. Eight adult New Zealand white rabbits were used in this study. Four defects were surgically made in their calvaria. Using a trephine bur, 4 'through and through' defects were created and classified into 4 groups, which were consisted of control (no graft), experimental group 1 (autogeonous bone) and experimental group 2 (deproteinized bovine bone: OCS-B®; NIBEC, Korea), experimental group 3 (synthetic bone: MBCP; Biomatlante, France). The defects were covered with PTFE membrane (Cytoplast®, Innova, Canada). Membranes were removed after 1, 2, 4 and 8 weeks post-GBR in each 2 rabbits. And then, all rabbits were sacrificed; specimens were taken and observed histologically..: After removing the membranes after 1 week of the experiment, bone formation was not evident in a control group but the area was replaced with only loose fibrous connective tissue. In group 1(autogeonous bone), thin bone formation and infiltration of connective tissue on the superficial layer were observed. Initial bone formation and infiltration of fibrous connective tissue were evident in group 2(deprotenized bovine bone) and 3(synthetic bone). When the membranes were removed after 2 weeks of the experiment, bridge shaped bone formation was shown in control group but mostly connective tissue took place. More increased bone thickness was evident in group 1 and increased bone formation than first week was shown in group 2 and 3. When the membranes were removed after 4 weeks of the experiment, 2/3 of normal bone thickness was formed in control group still with infiltration of connective tissue. In group 1, regular bone formation with normal bone thickness was shown and in group 2 and 3, similar bone thickness to the normal was evident. After the removal of the membranes in 8 weeks, bone thickness formed in control group was more increased than 4th week, but could not reach normal bone thickness. In group 1, normal bone thickness was formed and similar bone thickness to that of the normal was observed in group 2 and 3. Within the limited study, when performing the GBR procedure, at least 4-week period of the membrane retention is required, and more retention time of the xenograft or synthetic bone is needed than that of autogenous bone for better bone regeneration.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».