P20: Understanding the impact of a cure for hepatitis C from the patient perspective
Notice bibliographique
Résumé
Hepatitis C virus (HCV) infection and treatment can have significant health-related quality-of-life (HRQoL) and clinical impacts (1). As many patients undergoing treatment for HCV are relatively asymptomatic, it is unclear how HRQoL domains such as social stigma or the knowledge of having HCV are impacted by being cured with HCV treatment. The objective of this research was to explore the meaning and effects of being cured of HCV from the patient perspective. Canadian adults diagnosed with HCV were recruited by a market research firm; recruitment was stratified according to whether individuals were treatment-naïve, currently- or previously-treated but not cured, or cured. All eligible participants completed one-on-one qualitative interviews with trained interviewers. The interviews were semi-structured, following an interview guide developed through literature review and clinical expert consultation, and included both open-ended and focused questions on perceptions of the HRQoL impacts of HCV, and the impacts of being cured. All interviews were transcribed and a thematic analysis was conducted using MaxQDA software to identify key concepts associated with being cured of HCV. A conceptual model was developed to illustrate the relationships between the themes. The twenty-five interviews were conducted among eight treatment-naïve, nine currently- or previously-treated but not cured, and eight cured participants. The mean age was 52 years; 80% were male. Key themes pertaining to HCV infection included fear of worsening health, especially liver disease and death; fear of infecting others; and reduced energy. Although patients acknowledged that treatment caused emotional and physical side effects, the vast majority perceived that treatment was worthwhile for a chance of a cure. Patients noted numerous potential impacts of a cure, including being relieved, regaining energy, improvements in close relationships and self-esteem, reduced mental burden and stress about future health, reduced feelings of isolation, and a general improvement in mood and positive outlook on life. Findings from these qualitative interviews demonstrate that HCV infection imposes a substantial psychosocial burden among patients. This research highlights the many areas where patients may benefit from being cured of HCV. 1. Spiegel BMR, Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F. Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment. Hepatology 2005; 41(4): 790–800.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,010 | 0,013 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,009 | 0,018 |
| Communication savante | 0,008 | 0,009 |
| Science ouverte | 0,002 | 0,007 |
| Intégrité de la recherche | 0,004 | 0,008 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».