One-in-a-million; the first community trial of water fluoridation

During the 1930s and early 1940s, H Trendley Dean and his colleagues working from the US National Institutes of Health published a series of epidemiological studies describing the relationship between the level of fluoride naturally present in public drinking-waters and the prevalence and severity of dental fluorosis (1) and dental caries. (2) Dental fluorosis is a white--and in more severe cases an unsightly brown--developmental defect of dental enamel, while dental caries is a post-eruptive disease of the teeth caused by the action of certain oral bacteria on ingested dietary sugars. As the natural fluoride level rises from low levels (less than 0.1 mg/1), so the prevalence and severity of dental fluorosis increase while the extent of dental caries--usually summarized by the index of the mean number of decayed, missing and filled teeth (DMFT)--falls. Dean and his colleagues (3) suggested that in temperate climates and at a fluoride concentration in drinking-water of around 1 mg/l, the level of dental caries was substantially less than that associated with low levels of fluoride, while the level of dental fluorosis had increased but only to a level that was clinically and aesthetically of concern. Furthermore, in parallel studies significant other health effects could be seen in areas with fluoride levels in public drinking-water even as high as 8 mg/l. For example, a study in Bartlett, Texas, (4) reported on potential health effects in people with long-term residence of at least 15 years who consumed public water with a natural fluoride level of 8 mg/l, compared with long-term residents of nearby Cameron where the fluoride level was 0.4 mg/1. Ibis study, involving a medical history, physical and dental examinations, X-ray, and blood and urine analyses, was conducted in 1943 and repeated in 1953. For the important bone changes the study reported that only 10-15% of humans who consumed a water supply with an excessive fluoride content (8 mg/l) for a long time may show radiographic (but not clinical) evidence of bone changes. The authors concluded: no clinically significant physiological or functional effects resulted from prolonged ingestion of water containing excessive fluoride except for dental fluorosis. In the light of these and similar studies it was not surprising that a hypothesis was formulated that the adjustment of the fluoride level of public drinking-water supplies to 1 mg/1 might have similar effects to naturally fluoridated water. To test this, a controlled community water fluoridation trial in the city of Grand Rapids started on 25 January 1945, with the nearby city of Muskegon acting as a control. Although this was the first water fluoridation trial, at least three other trials were established in the United States and Canada within the next year or so. The first dental data from the Grand Rapids--Muskegon study were published in 1950 (5) and reported baseline data collected in 1944-45 based on examinations of all 28 614 children in Grand Rapids and all 7786 children in Muskegon aged 4-16 years, together with follow-up data collected in 1949. Annual examination of selected samples of children continuously resident in Grand Rapids continued for 15 years. Muskegon remained the non-fluoridated control city until July 1951, at which time, in response to the observed effects in Grand Rapids, city officials decided to fluoridate the supply in Muskegon also. Annual dental examinations of samples of children continuously resident continued for a further three years in Muskegon and provided some of the data in the 1956 report by Arnold et al., (6) extracts of which are reproduced below. The authors presented age-specific data for children aged 4-13 years for deciduous teeth and 6-16 years for permanent teeth and noted that water fluoridation was remarkably effective in reducing the incidence of dental caries in both groups. Data for Grand Rapids after 15 years of fluoridation were published by Arnold et al. …

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.