Translational research: an important integrated paradigm for transfusion medicine
Notice bibliographique
Résumé
Translational research (TR) has many different potential definitions. There are two broad elements: one is research that serves as a bridge between basic science and the development/use of a therapeutic product/intervention; the second (also known as knowledge translation) explores why a clinically established product is not used more widely and/or further characterizes its optimal use. The first TR element has always been an integral part of transfusion medicine; it has previously been referred to as applied research or development. TR includes animal model research, and Phase I, II, and I/II clinical trials using human volunteers to determine safety and start evaluating efficacy of a novel therapy; some TR definitions also include definitive Phase III randomized controlled trials. TR usually needs a different infrastructure than basic research; funding may require public (government or university) and private (commercial companies) partnerships. Conducting TR requires a strong understanding of regulatory requirements and often necessitates the establishment of national or international multi‐center research programs supported by sophisticated information technology and a clinical coordinating center well versed in these disciplines. To this end, the National Heart, Lung, and Blood Institute in the U.S. not only offers its usual funding mechanisms but has also developed several other funding mechanisms to better support and coordinate such activities. There are multiple examples of successful TR in transfusion medicine; these include nucleic acid testing for infectious disease agents, the use of monoclonal antibodies in immunohematology, and the transfusion of pathogen inactivated platelet and plasma products in many countries. Scientific questions addressed by animal model research include red cell alloimmunization, graft versus host disease, transfusion related immunomodulation, and transfusion related acute lung injury. A new area of transfusion medicine TR is the production of functional mature RBCs from cultures of embryonic stem cells. The issue of how to best conduct TR still remains; challenges include finding mechanisms to adequately fund technological and product development, overcoming regulatory obstacles to the licensing of new technologies, and designing and funding large clinical trials to answer many of the remaining questions about transfusion triggers and best transfusion practices. The knowledge translation component of TR offers additional challenges; these require a different set of investigator skills and infrastructure in order to evaluate the effectiveness of interventions that can change clinical practice.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».