Impact of systemic lupus erythematosus organ damage on unemployment or disability from a population-based cohort
Notice bibliographique
Résumé
Systemic lupus erythematosus (SLE) predominantly develops in younger age groups, when many are establishing themselves in the workforce. The development of a chronic, autoimmune condition during this period can have a devastating impact on employment. The objective was to determine the impact of different organ damage in patients with SLE on employment loss from a large, population-based cohort. The source of data was from the 2011 to 2012 annual patient-reported survey of the Georgians Organized Against Lupus (GOAL) Study, an ongoing population-based cohort of patients with validated SLE in Atlanta, GA assembled primarily from the Georgia Lupus Registry (GLR). The GLR was supported by the Centers for Disease Control and Prevention and designed to more accurately estimate the incidence and prevalence of SLE. In partnership with the state health department, the GLR was able to access protected health information without patient consent. GOAL Study participants were surveyed regarding employment status at the time of survey completion along with other demographic information. Organ damage was measured using the Brief Index of Lupus Damage. Disease activity was measured using the SLE Activity Questionnaire (SLAQ). Logistic regression analysis was used to measure the association between categories of organ damage and unemployment/disability. A total of 459 SLE patients were surveyed with a mean age of 46.5 (SD ± 10), 13.4 (SD ± 8.6) years of disease, and 14.2 (SD ± 2.8) years of education; 93.2% were female, 79.5% were black and 14.4% white. One hundred and ninety-seven (42.9%) were working and 262 (57.1%) were unemployed/disabled. The median duration of loss of employment was 7.1 years (IQR 3.1 to 12.3). See Table 1 . In total, 57.1% of SLE patients were unemployed or disabled at the time of the survey. Organ damage from SLE has a profound association with unemployment/disability. In the multivariate model, low education level and depression were independently associated with unemployment/disability. In line with other studies, cardiovascular and renal damage were associated with unemployment/disability. Previous studies have not reported disease activity (SLAQ) as a mediator and should be considered particularly when evaluating neuropsychiatric damage and its association with employment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».