The Balance between Thrombosis and Bleeding in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Notice bibliographique
Résumé
Copyright: © 2014 Labrador J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Patients with cancer have disturbances in the hemostasis which translates into an increased incidence of Thromboembolic Events (TEEs) as patients without cancer [1]. In addition, the presence of TEEs in cancer patients is associated with a poor prognosis [2]. Historically, among cancer patients, the incidence of thrombotic complications has been more frequent in solid tumors (especially carcinoma of the pancreas or brain tumors) with respect to hematological malignancies [1]. But recently, it is begun to recognize that the incidence of TEEs in hematological neoplasms is similar to that of solid tumors [3]. However, little is known about the incidence of TEEs in patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT). The first published studies in this setting showed that HSCT recipients also develop TEEs, including venous thromboembolisms [46] and arterial events [7,8]. Therefore, a thromboprophylaxis strategy could be useful in selected patients after HSCT. However, this high incidence of TEEs in allogeneic HSCT has been analyzed without taking into consideration the high risk of bleeding of these patients due to prolonged severe thrombocytopenia and tissue damage caused by conditioning regimen or complications after HSCT [4,6,9-12]. Based on that, an analysis of the competing risks of hemorrhagic and TEEs in allogeneic HSCT recipients [13] showed that bleeding complications were more frequent than TEEs (the cumulative incidence at 14 years for bleeding episodes was 30.2% vs. 11.8% and 4.1% for venous and arterial TEEs, respectively). The development of extensive chronic Graft Versus Host Disease (GVHD) was the only risk factor for the occurrence of venous TEEs [OR=2.85, 95% CI (1.20-6.80)]. While advanced disease status, myeloablative conditioning regimen, HSCT from umbilical cord, anticoagulation after HSCT, grade acute III-IV GVHD and thrombotic microangiopathy were associated with an increased risk of bleeding. But the most important issue was that bleeding episodes were associated with increased mortality, while TEEs were not. The median overall survival of patients with bleeding episodes was only 15 months, as compared to patients without bleeding episodes (122 months) (p<0.001) [13]. Of note, the use of anticoagulation after allogeneic HSCT appeared predisposed to developing bleeding, so venous thromboprophylaxis should carefully considered in selected allogeneic HSCT recipients (such as patients with extensive chronic GVHD). However, since we do not know the efficacy and safety of anticoagulation in this population, more studies are needed to answer this question. References
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».