Endurance exercise, tryptophan availability to the brain, and sleep electrophysiology in older men
Notice bibliographique
Résumé
Normal aging entails significant changes in serotonergic activity and function. Noteworthy, these alterations might predispose older individuals to develop depressive symptoms and contribute to age-related changes in sleep. This study verified if exercise increases tryptophan (Trp) availability to the brain and affects sleep depth and architecture in older men. Nineteen men (aged 64 ± 3 years) undertook a series of 4 tests, which was repeated at follow-up (after 16 weeks of training) as follows: (i) dual-energy X-ray absorptiometry (body composition); (ii) peak O2 consumption, ventilatory threshold, and respiratory compensation point (cardiopulmonary testing); (iii) blood withdrawals immediately before, during, and after exercise for analysis of glucose, lactate, ammonia, free fatty acids (FFA), total proteins, albumin, prolactin, valine, leucine, isoleucine, adiponectin, leptin, free and total Trp, and calculated variable: branched-chain amino acids (BCAA); and (iv) sleep electrophysiology (wake, stage 1, stage 2, stages 3+4 or slow-wave sleep (SWS), stage 5 or rapid eye movements, movement time, leg movements during sleep, apneas, hypopneas, and derivative variables). The intervention consisted of supervised exercise (3× per week × 45 min, 65%–70% peak oxygen uptake (V̇O2peak) whereas experimental exercise consisted of 1 h of inclined treadmill (∼68% V̇O2peak). Variations in serum prolactin and free Trp/BCAA served as proxies of 5-hydroxytryptamine activity and synthesis rate, respectively. A series of 3 nights was assessed before and after training using laboratory-based sleep electrophysiology (polysomnography: electroelectroencephalography and electromyography and electro-oculography) as follows: (i) familiarization, (ii) inactive trial, and (iii) exercise trial. Aerobic taining increased oxygen uptake at both ventilatory thresholds, whereas body mass decreased. Acute exercise increased free Trp/BCAA ratio by more than 100% of that at rest and remained elevated postexercise. This ratio shared a positive association with FFA levels. After 1 h of exercise, prolactin was higher than that at rest and was positively associated with free Trp/BCAA. However, the acute response to exercise was attenuated following training for many compounds, including free Trp/BCAA, prolactin, lactate, and FFA. Analyses revealed significant main effects of exercise on wake after sleep onset, rapid eye movement onset latency, and time awake overnight. As compared with the inactive trial at baseline, a higher proportion of SWS was observed during the night subsequent to exercise following training. In addition, we found a positive association between resting adiponectin and SWS. The results support the hypothesis that increases in serotonin synthesis and activity might be involved in the antidepressant outcome of exercise in older men. Inasmuch as training lowered the increase in Trp supply during exercise, Trp requirement by the brain in response to exercise might be attenuated by training. Despite gains in cardiorespiratory fitness after training, a day without exercise led to SWS values similar to those at baseline. However, exercise increased the proportion of SWS during subsequent sleep but this could only be found after training. These results provide evidence that not only sleep quantity (duration) but also quality (SWS) could affect circulating adiponectin levels. Finally, a positive correlation was found between sleep depth and circulating adiponectin levels.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».