Alcohol in Canada: reducing the toll through focused interventions and public health policies
Notice bibliographique
Résumé
<b>3021</b> <h3><b>Objectives:</b></h3> In the United States, Lutetium-177 is being used to treat patient’s with gastro-entero-pancreatic neuroendocrine tumors with the FDA approved radiopharmaceutical Lutathera, which is manufactured by Advanced Accelerator Applications. In addition, Radiomedix, is manufacturing Lutetium-177-PSMA to treat patients with metastatic prostate cancer as part of a phase III clinical trial which is run by Endocyte. Each company uses a different process to manufacture the Lutetium, one of which adds a small amount of metastable Lutetium-177 which has a 160.4 day half-life. Without the metastable component, Lutetium-177 has a 6.65 day half-life. The difference in manufacturing methods may lead to differences in handling and disposing of the radioactive material. The purpose here is to share a single institution’s experience, OHSU, with Lutetium-177 from different manufacturers. <h3><b>Methods:</b></h3> After administration of the radionuclide therapy, any radioactive waste is stored in a secure area to decay in storage. With a half-life of 6.65 days, our process is to check for any residual activity at approximately 65 days or 10 half-lives. After this decay period, we compared residual activity in multiple vials between manufacturer’s which had the same calibration date or were within one or two days of each other. To do this comparison, we measured the vial in a dose calibrator and also withdrew 1cc from each vial and measured the counts per minute in a Perkin Elmer Wizard well counter. <h3><b>Results:</b></h3> When comparing waste from each manufacturer which had the same calibration date or were within one or two days of each other, we noticed that measured counts per minute from the well counter were 200% higher for vials from AAA. This phenomenon is consistent across all vials that were compared. We believe this is directly correlated to the metastable component that can be found in Lutetium-177 from AAA. The prolonged presence of radioactivity in the vials from AAA have required us to use a third-party company for disposal of this radioactive waste, which has led to increase in space needed for decay in storage and an additional operating cost to properly handle this material. <b>Conclusion:</b> In summary, Lutetium-177 has become a vital tool for radionuclide therapy, however, there are important considerations for decay and disposal of the radioactive waste which will vary based on the method of production. Having this information available when starting new programs and service lines is critical to long term success and compliance with regulatory agencies.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».