Tumor Paint: A Chlorotoxin:Cy5.5 Bioconjugate for Intraoperative Visualization of Cancer Foci
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Development of a chlorotoxin bioconjugate for intraoperative cancer visualization; the object is an imaging agent.
It develops an optical cancer-imaging agent, not a study of research.
Cancer imaging bioconjugate (tumor paint); translational oncology tool, not research-on-research.
Résumé
Toward the goal of developing an optical imaging contrast agent that will enable surgeons to intraoperatively distinguish cancer foci from adjacent normal tissue, we developed a chlorotoxin:Cy5.5 (CTX:Cy5.5) bioconjugate that emits near-IR fluorescent signal. The probe delineates malignant glioma, medulloblastoma, prostate cancer, intestinal cancer, and sarcoma from adjacent non-neoplastic tissue in mouse models. Metastatic cancer foci as small as a few hundred cells were detected in lymph channels. Specific binding to cancer cells is facilitated by matrix metalloproteinase-2 (MMP-2) as evidenced by reduction of CTX:Cy5.5 binding in vitro and in vivo by a pharmacologic blocker of MMP-2 and induction of CTX:Cy5.5 binding in MCF-7 cells following transfection with a plasmid encoding MMP-2. Mouse studies revealed that CTX:Cy5.5 has favorable biodistribution and toxicity profiles. These studies show that CTX:Cy5.5 has the potential to fundamentally improve intraoperative detection and resection of malignancies.
Conservé avec la notice de tri, où il sert de preuve aux étiquettes ci-dessus.
La notice
- Revue
- Cancer Research
- Thématique
- Nanoplatforms for cancer theranostics
- Domaine
- Engineering
- Établissements canadiens
- Immunovaccine (Canada)
- Organismes subventionnaires
- National Cancer InstituteU.S. Public Health Service
- Mots-clés
- CancerBiodistributionCancer researchIn vivoCancer cellBioconjugationChemistryPathologyRous sarcoma virusIn vitroMedicineBiologyInternal medicineBiochemistry
- Résumé présent dans OpenAlex
- oui