Tumor Paint: A Chlorotoxin:Cy5.5 Bioconjugate for Intraoperative Visualization of Cancer Foci
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Development of a chlorotoxin bioconjugate for intraoperative cancer visualization; the object is an imaging agent.
It develops an optical cancer-imaging agent, not a study of research.
Cancer imaging bioconjugate (tumor paint); translational oncology tool, not research-on-research.
Abstract
Toward the goal of developing an optical imaging contrast agent that will enable surgeons to intraoperatively distinguish cancer foci from adjacent normal tissue, we developed a chlorotoxin:Cy5.5 (CTX:Cy5.5) bioconjugate that emits near-IR fluorescent signal. The probe delineates malignant glioma, medulloblastoma, prostate cancer, intestinal cancer, and sarcoma from adjacent non-neoplastic tissue in mouse models. Metastatic cancer foci as small as a few hundred cells were detected in lymph channels. Specific binding to cancer cells is facilitated by matrix metalloproteinase-2 (MMP-2) as evidenced by reduction of CTX:Cy5.5 binding in vitro and in vivo by a pharmacologic blocker of MMP-2 and induction of CTX:Cy5.5 binding in MCF-7 cells following transfection with a plasmid encoding MMP-2. Mouse studies revealed that CTX:Cy5.5 has favorable biodistribution and toxicity profiles. These studies show that CTX:Cy5.5 has the potential to fundamentally improve intraoperative detection and resection of malignancies.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Cancer Research
- Topic
- Nanoplatforms for cancer theranostics
- Field
- Engineering
- Canadian institutions
- Immunovaccine (Canada)
- Funders
- National Cancer InstituteU.S. Public Health Service
- Keywords
- CancerBiodistributionCancer researchIn vivoCancer cellBioconjugationChemistryPathologyRous sarcoma virusIn vitroMedicineBiologyInternal medicineBiochemistry
- Has abstract in OpenAlex
- yes