Notice bibliographique
Résumé
The nature of the relationship between the mind and the body has preoccupied philosophers and physicians for centuries. In current discussions of health and disease, this subject and its implications for well-being are frequently pointed out in the media and are of great interest to the public. For example, contemporary thinking concerning the increasing prevalence of chronic inflammatory diseases (such as allergic asthma) bases itself on the assumption that psychological stress, via neuroendocrine and immunologic networks and changes in homeostasis, can influence lung function and thus expression of disease. There is indeed evidence that stress can induce attacks of asthma and may also cause asthma to develop. Unfortunately, the literature in these fields is large, complex, and often confusing. Nonetheless, we are quickly gaining a broader understanding of some of the cellular and molecular mechanisms that mediate environmental perturbations, through stress, to cause dysregulated physiologic responses, eventuating in chronic inflammatory diseases such as allergies. Stressful stimuli early in life can have long-lasting impacts on mind-body pathways, and physiologic and pathophysiologic responses, later in life. Recent discoveries have shown that stress-related epigenetic changes and associated alterations in gene expression in early (even fetal) life can lead to long-lasting impacts on adult health and disease; such studies may identify novel therapeutic pathways and targets for control of many chronic diseases. It is becoming clear that a more thorough understanding of the nature and extent of mind-body pathways is essential if we are to develop novel and effective management strategies for allergic and other chronic diseases. As part of a rigorous participatory process to identify fundamental gaps in our knowledge and to develop a strategic research plan, AllerGen NCE Inc., a recently funded Canadian Network of Centres of Excellence, held a workshop on the mind-body of allergic diseases in Hamilton, Ontario, on February 14, 2007, which brought together over 25 clinicians, scientists, and trainees to learn about this exciting and rapidly advancing field and to initiate discussions that would lead to development of a strategic research plan on mind-body issues in allergic diseases. Outstanding invited speakers provided state-of-the-art presentations at the workshop, which are highlighted in this issue of the journal. Dr. Rosalind Wright provides a most informative summary and assessment of the relationship of stress to the risk of development of childhood asthma. Dr. Firdaus Dhabhar contributes a scholarly review of the often opposing effects of acute and chronic stress on the immune system and on host defences and immunopathology. Dr. Glenda MacQueen and her colleague Dr. Ryan van Lieshout provide a comprehensive review of the role of psychological factors, including cognitive function and depressive disorders, in the expression of asthma, discussing the implications of these findings for psychological and other therapeutic interventions. Dr. Moshe Szyf and his colleague Dr. Michael Meaney supply a cutting-edge update on epigenetics and early-life events that can influence behaviour and health and disease later in life. We are most enthusiastic about the excellence of these written reviews and are pleased that the journal is making these internationally available to practicing allergists, scientists, and others. The contributions by the speakers at the workshop were instrumental in fostering the beginnings of programmatic research activities in the mind-body field for AllerGen NCE Inc. Moreover, the reviews provide important information, a tool for reflection, and a stimulus for research and development that in the future will greatly benefit those with allergic and other inflammatory diseases.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,002 | 0,007 |
| Communication savante | 0,004 | 0,003 |
| Science ouverte | 0,001 | 0,003 |
| Intégrité de la recherche | 0,003 | 0,006 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,002 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».