Periocular sebaceous gland carcinoma: do androgen receptor (<scp>NR</scp>3<scp>C</scp>4) and nuclear survivin (<scp>BIRC</scp>5) have a prognostic significance?
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Immunohistochemical biomarker study in sebaceous gland carcinoma; clinical pathology.
This studies prognostic markers in carcinoma, not research practice.
Clinical oncology study of prognostic markers in periocular sebaceous carcinoma.
Résumé
PURPOSE: The study aimed at evaluating the expression of androgen receptor (AR) and nuclear survivin (NS) in periocular sebaceous gland carcinoma (SGC) and to determine whether this expression is associated with histopathological features, markers of apoptosis and proliferation and with clinical outcomes. METHODS: This was a retrospective, comparative case series which included 56 patients with a biopsy-proven periocular SGC. Immunohistochemical staining for AR, survivin, p53 and Ki-67 was analysed in all cases. RESULTS: All patients expressed AR, p53 and Ki-67 in the nucleus of tumour cells. Twenty-four patients (42.8%) had a high AR score, and 32 patients (57.2%) had a low AR score. Twenty-four (42.8%) patients expressed survivin in the nucleus of tumour cells. Nine (37.5%) had a high NS score, and 15 (62.5%) had a low NS score. Patients with a high AR score had a greater recurrence (p < 0.005), higher expression of Ki-67 (p < 0.0001) and a lower p53 expression (p < 0.005). Nuclear expression of survivin correlated with a high Ki-67 labelling index (0.0001) and low p53 expression (<0.005). Neither nuclear expression of survivin nor the NS score correlated with any clinicopathological features. CONCLUSION: Expression of AR significantly impacts prognosis and is thus promising prognostic marker in periocular SGC.
Conservé avec la notice de tri, où il sert de preuve aux étiquettes ci-dessus.
La notice
- Revue
- Acta Ophthalmologica
- Thématique
- Nonmelanoma Skin Cancer Studies
- Domaine
- Medicine
- Établissements canadiens
- Vancouver General HospitalUniversity of British Columbia
- Organismes subventionnaires
- Hyderabad Eye Research Foundation
- Mots-clés
- SurvivinImmunohistochemistryAndrogen receptorMedicineApoptosisCancer researchPathologyCarcinomaBiopsyInternal medicineOncologyBiologyCancer
- Résumé présent dans OpenAlex
- oui