363 THE IMPACT OF MULTIPLE BIOPSIES ON ERECTILE AND VOIDING FUNCTION AFTER RADICAL PROSTATECTOMY: A POPULATION-BASED ASSESSMENT

You have accessJournal of UrologyProstate Cancer: Localized (I)1 Apr 2013363 THE IMPACT OF MULTIPLE BIOPSIES ON ERECTILE AND VOIDING FUNCTION AFTER RADICAL PROSTATECTOMY: A POPULATION-BASED ASSESSMENT Florian Roghmann, Vincent QH Trinh, Hugo Lavigueur-Blouin, Andreas Becker, Malek Meskawi, Al'a Abdo, Joachim Noldus, Pierre I Karakiewicz, Quoc-Dien Trinh, and Maxine Sun Florian RoghmannFlorian Roghmann Herne, Germany , Vincent QH TrinhVincent QH Trinh Montreal, Canada , Hugo Lavigueur-BlouinHugo Lavigueur-Blouin Montreal, Canada , Andreas BeckerAndreas Becker Hamburg, Germany , Malek MeskawiMalek Meskawi Montreal, Canada , Al'a AbdoAl'a Abdo Montreal, Canada , Joachim NoldusJoachim Noldus Herne, Germany , Pierre I KarakiewiczPierre I Karakiewicz Montreal, Canada , Quoc-Dien TrinhQuoc-Dien Trinh Montreal, Canada , and Maxine SunMaxine Sun Montreal, Canada View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1750AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A previous study showed that a delay in radical prostatectomy (RP) after prostate cancer (PCa) diagnosis is associated with worse functional outcomes postoperatively. Since delay of RP likely results in increased number of prostate biopsies (PBx), we hypothesized that increasing number of PBx prior to RP was associated with higher rates of erectile dysfunction (ED) and urinary incontinence postoperatively. METHODS Overall, 10,743 men without a baseline diagnosis of ED or incontinence who underwent RP for non-metastatic clinical stage T100FB;2, low-grade PCa between years 1995 and 2005 within the U.S. Surveillance, Epidemiology, and End Results Medicare-linked database were identified. For each patient, the number of PBx prior to RP was abstracted, and dichotomized as <2 vs. ≥2. Postoperative functional outcomes consisted of urinary incontinence and ED diagnosis/procedure. Univariable and multivariable logistic regression analyses were performed. Covariates consisted of patient age at diagnosis, race, baseline comorbidities, clinical tumor stage, year of diagnosis, Metropolitan areas, marital and socioeconomic status. RESULTS Overall, 7739 (71.8%) and 3004 (28.2%) patients had <2 or ≥2 PBx prior to RP, respectively. Patients who received ≥2 PBx prior to RP had higher rates of ED diagnosis (36.6 vs. 31.3%) and procedure (5.8 vs. 4.9%), as well as urinary incontinence diagnosis (31.4 vs. 24.8%) and procedure (24.8 vs. 18.5%, all P<0.001). After accounting for all other confounders, patients with ≥2 PBx prior to RP were respectively 20 and 10% more likely to experience an ED diagnosis and procedure postoperatively (both P≤0.01). Similarly, ≥2 PBx was associated with respectively 18 and 23% higher risk of postoperative urinary incontinence diagnosis and procedure, (both P<0.001). CONCLUSIONS Patients who receive multiple PBx prior to RP for clinically localized PCa may be at risk of higher rates of ED and urinary incontinence postoperatively. Such concerns should be communicated to patients during counseling. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e147 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Florian Roghmann Herne, Germany More articles by this author Vincent QH Trinh Montreal, Canada More articles by this author Hugo Lavigueur-Blouin Montreal, Canada More articles by this author Andreas Becker Hamburg, Germany More articles by this author Malek Meskawi Montreal, Canada More articles by this author Al'a Abdo Montreal, Canada More articles by this author Joachim Noldus Herne, Germany More articles by this author Pierre I Karakiewicz Montreal, Canada More articles by this author Quoc-Dien Trinh Montreal, Canada More articles by this author Maxine Sun Montreal, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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