The assessment of olivocochlear function in neonates with real‐time distortion product otoacoustic emissions
Notice bibliographique
Résumé
OBJECTIVES/HYPOTHESIS: Otoacoustic emissions (OAE) can be suppressed with activation of the medial olivocochlear neural pathway by stimulation of the contralateral ear. The primary objective of this study was to assess the feasibility of using olivocochlear mediated OAE suppression to test neonatal hearing with a novel device that detects changes in distortion product (DP)OAE level with high temporal resolution. The secondary objective was to investigate whether temporal parameters of the response can be determined with this technique and used in the assessment of neonates at risk of auditory neuropathy spectrum disorder (ANSD). STUDY DESIGN: Prospective translational study of novel hearing assessment technique. METHODS: There were 46 neonates tested in a clinic or neonatal intensive care unit (NICU). DPOAE were recorded in real time with narrow band pass digital filtering (1 ms temporal resolution) during presentation of an intermittent contralateral broadband noise stimulus. Magnitude and latency of the contralateral suppression response were compared with hearing outcome (auditory brainstem response screen and clinical follow-up) and risk factors for hearing loss, particularly hyperbilirubinemia as a risk factor for ANSD. RESULTS: : Contralateral suppression was identified in all of 38 neonates with detectable DPOAE and normal hearing, most reliably at f(2) = 4.4 kHz (average values = 1 dB suppression from DP level of 14 dB SPL using 0.55 s contralateral stimulus at 50 dB SPL). Sensorineural hearing loss was identified in three cases (6.5%) and ANSD in five cases (11% of all neonates tested). Contralateral suppression was absent in two of the ANSD cases (one associated with cochlear nerve aplasia, the other with hyperbilirubinemia) and present in three. The median latency for onset of contralateral suppression was 60 ms and offset latency 83 ms. The latency for offset of suppression was longer in neonates who required treatment for hyperbilirubinemia at 123 ms (P = .02, Mann-Whitney rank sum test). Latency measurements were determined with high intraobserver reliability (Pearson product moment correlation coefficient > 0.96). CONCLUSIONS: Contralateral suppression of real-time DPOAE can reliably be identified in neonates. This is likely a manifestation of olivocochlear activity, although middle ear muscle reflexes might contribute to suppression in some circumstances. The technique provides a feasible objective test of hearing in neonates that can be applied in the NICU setting without sedation. The presence of a response indicates detection of sound by the contralateral ear and effective brainstem transmission of neural signals, therefore providing a more sensitive test of hearing than OAE alone. The high temporal resolution of the technique allows measurement of latency of the response. These benefits help to identify neonates at risk of ANSD and have the potential to provide prognostic information that will assist in the management of this unpredictable disorder. Further development of the technique is indicated with regard to determination of hearing threshold, frequency specific testing, and automation of response detection.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».