Long-term health sequelae following E. coli and campylobacter contamination of municipal water. Population sampling and assessing non-participation biases.
Notice bibliographique
Résumé
BACKGROUND: Following bacterial contamination of a municipal water system in the rural town of Walkerton, Ontario, over 2,300 cases of acute gastroenteritis were documented. The Walkerton Health Study is currently underway to assess for long-term health sequelae among consenting inhabitants of Walkerton, related to the original outbreak. We explored whether the association between the acute exposure and preliminary long-term health outcomes may have been biased through differences between early- and late-recruited study participants. METHODS: Using multiple data sources, including the 1996 and 2001 Canadian Census, and records from the Regional Health Unit, hospital and Walkerton Health Study, we determined both sample representativeness and the anticipated effects of intensifying study participant recruitment. Selection bias was assessed by examining for differences between initial and late participants, and their subsequent risk of having hypertension, proteinuria and reduced renal clearance. RESULTS: Of the 4,315 participants, 2,756 were permanent residents of Walkerton, representing 55% of the town's total population. The sample was demographically similar to the population of interest, although statistically women were more likely to participate than men (55% of sample were women compared to 52% of population, p<0.01), and the proportion of both young and very elderly adults was smaller than expected (13% of sample were > or = 65 years of age compared to 18% of population, p<0.01). Comparing the initial 3,959 participants to the 356 persons additionally recruited with substantial effort, the latter were more likely to be free of symptoms during the outbreak (21% vs. 7%, p<0.001), but were otherwise similar in terms of age, sex, the use of medical care resources and underlying health state predating the outbreak. The risk of long-term hypertension or renal sequelae did not significantly differ between initial and late study recruits. CONCLUSIONS: Participants in the Walkerton Health Study represent the population of interest, and comprise those who were acutely ill during the infected water outbreak. The available study sample should provide reasonably unbiased estimates of the associated risk between acute bacterial gastroenteritis and long-term health sequelae.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».