Can Follow-up Electrodiagnostic Studies in Patients with CIDP That Improved Following IGIV-C Treatment Predict Relapse after Treatment Discontinuation? (P4.106)
Notice bibliographique
Résumé
OBJECTIVE: Determine whether follow-up electrodiagnostic (EDX) studies in patients with CIDP that improved following IGIV-C treatment can predict clinical relapse. BACKGROUND: EDX studies performed during initial evaluation are not routinely repeated after improvement, stabilization or preceding treatment suspension. There are no data regarding whether follow-up EDX studies can predict clinical relapse. DESIGN/METHODS: We analyzed data from serial EDX studies from subjects in the ICE clinical trial [immune globulin intravenous, 10% caprylate/chromatography purified (IGIV-C) CIDP efficacy] who responded to IGIV-C treatment and were subsequently re-randomized to placebo group in an extension phase up to 6 months. EDX Study #1 was performed at baseline prior to treatment and EDX Study #2 was performed following the 6-month treatment phase. Studies were assessed for: total number of demyelinating range abnormalities, specific type of demyelinating abnormality and number of new demyelinating abnormalities noted in EDX Study #2. Comparisons were made between subjects who relapsed and those who did not. Statistical analysis was performed with Fisher’s exact test. RESULTS: Twenty-four subjects were evaluated: 11 Relapse and 13 No Relapse. In EDX Study #2, 64% (7/11) of the Relapse group had an increase in total number of demyelinating findings vs. 7% (1/13) of the No Relapse group (p=0.008). The total number of each demyelinating abnormality was tabulated. The No Relapse group had >40% decline in the number of each of the following abnormalities: prolonged distal motor latency, conduction block, temporal dispersion, prolonged duration distal compound muscle action potentials, F wave abnormalities; whereas, these values were unchanged or increased in the Relapse Group. There were no significant differences in new demyelinating findings. CONCLUSIONS: An increased total number of demyelinating findings in CIDP patients with clinical improvement following IGIV-C treatment may indicate a higher risk of clinical relapse following treatment cessation. Demyelinating EDX abnormalities can fluctuate while on treatment, possibly indicating some level of continuing disease activity. Certain EDX measures may be more predictive of relapse than others.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».