Regulation of mRNA Translation and Stability by microRNAs
Pourquoi ce travail est-il dans la base ?
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Résumé
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pairing to the mRNA 3'-untranslated regions to repress protein synthesis by mechanisms that are not fully understood. In this review, we describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA-mediated repression. We discuss the multiple, often contradictory, mechanisms that miRNAs have been reported to use, which cause translational repression and mRNA decay. We also address the issue of cellular localization of miRNA-mediated events and a role for RNA-binding proteins in activation or relief of miRNA repression.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
La notice
- Revue
- Annual Review of Biochemistry
- Thématique
- RNA Research and Splicing
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- McGill University
- Organismes subventionnaires
- Canadian Institutes of Health ResearchEuropean CommissionMcGill University
- Mots-clés
- microRNATranslation (biology)Psychological repressionMessenger RNAUntranslated regionBiologyPost-transcriptional regulationTranslational regulationRNA-binding proteinThree prime untranslated regionCell biologyArgonauteFunction (biology)Regulation of gene expressionGene expressionRNAComputational biologyGeneticsRNA interferenceGene
- Résumé présent dans OpenAlex
- oui