Human kallikrein-related peptidase 6 (KLK6) and 13 (KLK13) are involved in ovarian carcinoma pathogenesis
Notice bibliographique
Résumé
It is estimated in 2009 that 2500 Canadian women were diagnosed and 1750 women lost their lives to epithelial ovarian cancer. This malignancy has a high mortality rate because the majority of women are diagnosed in late stage disease where the 5 year survival rate is only 20%. Late diagnosis is a result of the lack of an effective screening marker. Currently, CA125 is the only marker that is used for ovarian cancer patients and it is used primarily to monitor disease recurrence after treatment. Unfortunately, CA125 lacks the sensitivity and specificity to be used for early detection of ovarian cancer. Recently, a new group of genes, the human kallikrein-related peptidase (KLK) family, has been implicated in ovarian cancer and are being investigated as potential new biomarkers for the malignancy. In particular, KLK 13 has been shown to have increased expression in ovarian cancer. KLK13 has increased expression in the ovarian cancer cell lines CAOV-3, OVCAR-3, and SKOV-3 when compared to the IOSE cell line and is involved in cell motility. Increased KLK13 expression increases migration in the epithelial cell lines IOSE and Mv1Lu. Also, when KLK13 expression was decreased in the ovarian cancer cell line SKOV-3, which has high endogenous KLK13 expression levels, there was a decrease in cellular migration. Increased KLK13 expression in IOSE cells increased cellular invasion through the basement membrane. These data together suggest KLK 13 plays a role in ovarian carcinogenesis and may be a potential therapeutic target. In order to see if KLK expression had any prognostic significance in ovarian cancer patients, paraffin embedded ovarian cancer samples were analyzed for KLK6 and KLK13 mRNA expression. High expression levels of both KLK6 and KLK13 were associated with invasive ovarian cancer. Also, high KLK6 expression was associated with late stage ovarian cancer and serous histological type. Both KLK6 and KLK13 were also shown to be markers of poor prognosis as patients with high kallikrein expression were more likely to have a recurrence than patients with low KLK expression. When KLK6, KLK13 and Mucl6 were assessed for the ability to detect ovarian cancer, the genes detected 56%, 50%, and 56%, respectively, early stage (Stage I and II) ovarian cancer patients. When all three markers were used in combination, the sensitivity of the test improved to 84%. There was no significant change in the specificity or positive predictive value, but the negative predictive value increased from 33% using the individual markers to 58% when all three markers were combined. These data together suggest KLK6 and KLK 13 are involved in ovarian cancer tumorigenesis. Both KLK6 and KLK13 are potential new markers and possible therapeutic targets for ovarian carcinoma.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».