Abstract P3-07-31: Case series of 21 patients with metastastic lobular breast carcinoma to the gastrointestinal tract
Notice bibliographique
Résumé
Abstract Background: Invasive lobular carcinoma comprises 5-15% of all breast cancer cases, with its incidence gradually increasing. While it is uncommon for breast cancer to metastasize to the gastrointestinal tract, lobular carcinoma has a disproportionately higher incidence of spread to the gastrointestinal (GI) system in comparison to other types of breast cancer. To date, most studies of gastrointestinal metastatic lobular carcinoma have been case reports and small case series. Aim: This study is a review of all cases of lobular breast cancer with gastrointestinal metastases seen at a University affiliated Tertiary Cancer Institute over a five-year period, examining demographic, epidemiological, medical, and treatment factors that may have an association with the risk of GI metastases. Methods: This is a retrospective chart review of all patients seen at the Cross Cancer Institute in Edmonton, Alberta, Canada between 2005-2010, with lobular breast cancer spread to the gastrointestinal tract. The outcomes of interest were: age at diagnosis, receptor status, site of primary breast cancer, stage at initial presentation, pathology, hormone receptor status, site of gastrointestinal metastasis, time from diagnosis of breast primary to gastrointestinal metastasis, time from diagnosis to death, time to gastrointestinal metastasis to death, and treatment regimen for both primary and metastatic disease. Results: 343 consecutive cases of lobular breast cancer were reviewed, and 21(6%) were found to have GI metastases. The mean age at initial diagnosis of primary tumor was 63 years. The site of primary breast cancer was most commonly in the outer upper quadrant. Stage at presentation of the breast primary was: Stage 1A = 17%, Stage 1B/2A = 17%, Stage 2B = 22%, Stage 3A = 11%, Stage 3B = 6%, Stage 3C = 17%, and Stage 4 = 11%. Receptor status of the primary breast cancer was as follows: HER2+ = 5%, PR+ = 76%, ER+ = 90%. The mean age at time of diagnosis of metastatic disease was 67 years. The main presenting symptoms of GI metastatic disease were:: small bowel obstruction (12.5%), incidental finding on endoscopy (12.5%), and incidental finding on imaging (12.5%). Sites of gastrointestinal spread included the stomach (52%), peritoneum (14%), duodenum (4%), jejunum (4%), transverse colon (4%), and pancreas (4%). Five-year survival from initial diagnosis of lobular breast cancer averaged 46%. Five-year survival from diagnosis of gastrointestinal metastasis was 29%. Conclusions: Approximately 1 in 20 patients diagnosed with a primary breast cancer of lobular pathology will have metastatic spread to the GI tract, presenting approximately 4 years after their initial primary diagnosis. The most common presentation of metastatic disease is small bowel obstruction, with the most common site of spread being the stomach. There remains a paucity of data in the literature and our project is one of the first to further characterize these patients. Future research is needed in developing treatment regimens for these patients, as the 5-year survival is only approximately 1 in 4. Citation Format: Noah J Switzer, Andrew Lim, Lillian Du, Katia Tonkin, Dan Schiller. Case series of 21 patients with metastastic lobular breast carcinoma to the gastrointestinal tract [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-07-31.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».